Effects of ethanol on behavioral temperature regulation in c57 and dba mice

L. I. Crawshaw; C. S. O'Connor; J. Duerr; J. C. Crabbe; J. K. Belknap

Effects of ethanol on behavioral temperature regulation in c57 and dba mice

L. I. Crawshaw, C. S. O'Connor, J. Duerr, J. C. Crabbe, J. K. Belknap

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Abstract

The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg"1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. T_sel was lower for the DBA mice, but within each strain T_sel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.

Original language	English (US)
Pages (from-to)	A4
Journal	FASEB Journal
Volume	10
Issue number	3
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

Cite this

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title = "Effects of ethanol on behavioral temperature regulation in c57 and dba mice",

abstract = "The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg{"}1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. Tsel was lower for the DBA mice, but within each strain Tsel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.",

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AU - Crawshaw, L. I.

AU - O'Connor, C. S.

AU - Duerr, J.

AU - Crabbe, J. C.

AU - Belknap, J. K.

PY - 1996

Y1 - 1996

N2 - The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg"1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. Tsel was lower for the DBA mice, but within each strain Tsel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.

AB - The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg"1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. Tsel was lower for the DBA mice, but within each strain Tsel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.

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Effects of ethanol on behavioral temperature regulation in c57 and dba mice

Abstract

ASJC Scopus subject areas

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