Effects of ethanol on behavioral temperature regulation in c57 and dba mice

L. I. Crawshaw, C. S. O'Connor, J. Duerr, J. C. Crabbe, J. K. Belknap

Research output: Contribution to journalArticlepeer-review


The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg"1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. Tsel was lower for the DBA mice, but within each strain Tsel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.

Original languageEnglish (US)
Pages (from-to)A4
JournalFASEB Journal
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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