Effects of ethanol on behavioral temperature regulation in c57 and dba mice

L. I. Crawshaw, C. S. O'Connor, J. Duerr, John Jr Crabbe, John Belknap

Research output: Contribution to journalArticle

Abstract

The effect of ethanol (EtOH) on temperature regulation was studied by placing C57 and DBA mice implanted with telemetry devices in a temperature gradient and injecting then with five doses of ethanol as well as NaCl vehicle. The doses ranged from 1.5 to 2.75 g'kg"1. Selected temperature (T,el), internal temperature (Tt) and activity were continuously monitored before and after the injections. Activity was greatly increased at the lowest dose, and was successively decreased at each higher dose. These effects were greater for DBA than for C57 mice. While Ti was initially higher in the DBA mice, Ti decreased following the injections in a similar dose related manner for both strains. Tsel was lower for the DBA mice, but within each strain Tsel did not vary with dose. EtOH has a greater effect on the activity of DBA than C57 mice, strain differences for the effects of EtOH on behavioral thermoregulation are less clear.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

Inbred DBA Mouse
Ethanol
ethanol
Temperature
mice
dosage
temperature
Telemetering
Thermal gradients
Telemetry
Injections
Body Temperature Regulation
injection
strain differences
thermoregulation
telemetry
temperature profiles
body temperature
Equipment and Supplies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Crawshaw, L. I., O'Connor, C. S., Duerr, J., Crabbe, J. J., & Belknap, J. (1996). Effects of ethanol on behavioral temperature regulation in c57 and dba mice. FASEB Journal, 10(3).

Effects of ethanol on behavioral temperature regulation in c57 and dba mice. / Crawshaw, L. I.; O'Connor, C. S.; Duerr, J.; Crabbe, John Jr; Belknap, John.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Crawshaw, LI, O'Connor, CS, Duerr, J, Crabbe, JJ & Belknap, J 1996, 'Effects of ethanol on behavioral temperature regulation in c57 and dba mice', FASEB Journal, vol. 10, no. 3.
Crawshaw, L. I. ; O'Connor, C. S. ; Duerr, J. ; Crabbe, John Jr ; Belknap, John. / Effects of ethanol on behavioral temperature regulation in c57 and dba mice. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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