Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

Cherie A. Singer; Pamela J. McMillan; Dorcas J. Dobie; Daniel M. Dorsa

doi:10.1016/S0006-8993(98)00142-5

Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

Cherie A. Singer, Pamela J. McMillan, Dorcas J. Dobie, Daniel M. Dorsa

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.

Original language	English (US)
Pages (from-to)	343-346
Number of pages	4
Journal	Brain research
Volume	789
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(98)00142-5
State	Published - Apr 13 1998
Externally published	Yes

Keywords

Aging
Basal forebrain
Choline acetyltransferase
Estrogen
Neurotrophins
trkA

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00142-5

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title = "Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats",

abstract = "The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.",

keywords = "Aging, Basal forebrain, Choline acetyltransferase, Estrogen, Neurotrophins, trkA",

author = "Singer, {Cherie A.} and McMillan, {Pamela J.} and Dobie, {Dorcas J.} and Dorsa, {Daniel M.}",

note = "Funding Information: The authors thank Mark Bothwell at the University of Washington for the trkA cDNA and Hidemi Misawa at the Tokyo Institute for Neuroscience for the ChAT cDNA. We also thank Jennifer Tullis for technical assistance. This work is supported by the Alzheimer's Disease Research Center USPHS Grant AG05136 and NS20311 to D.M.D., PHS Grant HDO07453-01 to P.J.M. and a molecular neurobiology training grant NS07332 to C.A.S.",

year = "1998",

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doi = "10.1016/S0006-8993(98)00142-5",

language = "English (US)",

volume = "789",

pages = "343--346",

journal = "Brain research",

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T1 - Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

AU - Singer, Cherie A.

AU - McMillan, Pamela J.

AU - Dobie, Dorcas J.

AU - Dorsa, Daniel M.

N1 - Funding Information: The authors thank Mark Bothwell at the University of Washington for the trkA cDNA and Hidemi Misawa at the Tokyo Institute for Neuroscience for the ChAT cDNA. We also thank Jennifer Tullis for technical assistance. This work is supported by the Alzheimer's Disease Research Center USPHS Grant AG05136 and NS20311 to D.M.D., PHS Grant HDO07453-01 to P.J.M. and a molecular neurobiology training grant NS07332 to C.A.S.

PY - 1998/4/13

Y1 - 1998/4/13

N2 - The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.

AB - The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.

KW - Aging

KW - Basal forebrain

KW - Choline acetyltransferase

KW - Estrogen

KW - Neurotrophins

KW - trkA

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AN - SCOPUS:0032513587

SN - 0006-8993

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JO - Brain research

JF - Brain research

IS - 2

ER -

Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

Abstract

Keywords

ASJC Scopus subject areas

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