Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

Cherie A. Singer, Pamela J. McMillan, Dorcas J. Dobie, Daniel M. Dorsa

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalBrain research
Volume789
Issue number2
DOIs
StatePublished - Apr 13 1998

Keywords

  • Aging
  • Basal forebrain
  • Choline acetyltransferase
  • Estrogen
  • Neurotrophins
  • trkA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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