Effects of estrogen and progestin on aortic size and compliance in postmenopausal women

G. D. Giraud, M. J. Morton, R. A. Wilson, K. A. Burry, L. Speroff, W. H. Hindle, C. March, C. Von der Ahe, R. Unzelman

    Research output: Contribution to journalArticle

    37 Scopus citations

    Abstract

    OBJECTIVE: Our purpose was to determine whether sex steroids alter aortic size and compliance in postmenopausal women. STUDY DESIGN: Twenty-six postmenopausal women were randomized to receive either conjugated estrogens 0.625 mg per day (group 1) or conjugated estrogens 0.625 mg per day and medroxyprogesterone 2.5 mg per day (group 2). Aortic cross-sectional area was measured by magnetic resonance imaging before and after 3 months of hormone therapy. RESULTS: Estradiol levels increased in both group 1 and group 2 (p < 0.0001). Ascending aortic cross-sectional area increased from 439 ± 7 mm2 to 466 ± 7 mm2 in group 1 (p < 0.006) but was unchanged in group 2. Within the range of aortic pressures studied, no change in aortic compliance could be detected. CONCLUSION: Estrogen therapy in postmenopausal women was associated with an increase in aortic size; but this effect was not detectable with the addition of progestin. The potential antagonistic effect of progestin on estrogen-induced aortic enlargement suggests that the favorable cardiovascular effects of postmenopausal estrogen therapy cannot be automatically extended to the combination estrogen-progestin.

    Original languageEnglish (US)
    Pages (from-to)1708-1718
    Number of pages11
    JournalAmerican journal of obstetrics and gynecology
    Volume174
    Issue number6
    DOIs
    StatePublished - Jan 1 1996

    Keywords

    • Estrogen
    • aorta
    • menopause
    • progestin

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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    Giraud, G. D., Morton, M. J., Wilson, R. A., Burry, K. A., Speroff, L., Hindle, W. H., March, C., Von der Ahe, C., & Unzelman, R. (1996). Effects of estrogen and progestin on aortic size and compliance in postmenopausal women. American journal of obstetrics and gynecology, 174(6), 1708-1718. https://doi.org/10.1016/S0002-9378(96)70201-6