Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress

J. Santesson, L. Irestedt, Per-Olof Järnberg, O. Norlander

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The influence on central hemodynamics of enflurane, in uniform anesthetic concentration (1.5 MAC), was studied in 10 normocapnic patients undergoing upper abdominal surgery. The patients were studied awake, during anesthesia prior to surgery, and during surgery. On institution of anesthesia, cardiac output (Q̇T) fell from 5.05 ± 0.51 to 4.12 ± 0.15 l/min and systemic vascular resistance (SVR) decreased from 2.36 ± 0.22 to 1.93 ± 0.18 kPa.min.l-3. The arteriovenous oxygen content difference (AVD) did not change. On commencement of surgery, AVD diminished from 38.5 ± 2.6 to 30.8 ± 1.9 ml/min and Q̇T rose to 5.82 ± 0.46 l/min, while SVR remained unchanged. It is concluded that the fall in Q̇T seen during enflurane anesthesia is caused by a diminished tissue oxygen demand. It is also suggested that enflurane acts as an α-blocking agent.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalActa Anaesthesiologica Scandinavica
Volume22
Issue number4
StatePublished - 1978
Externally publishedYes

Fingerprint

Enflurane
Hemodynamics
Oxygen
Anesthesia
Vascular Resistance
Cardiac Output
Anesthetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress. / Santesson, J.; Irestedt, L.; Järnberg, Per-Olof; Norlander, O.

In: Acta Anaesthesiologica Scandinavica, Vol. 22, No. 4, 1978, p. 381-390.

Research output: Contribution to journalArticle

Santesson, J. ; Irestedt, L. ; Järnberg, Per-Olof ; Norlander, O. / Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress. In: Acta Anaesthesiologica Scandinavica. 1978 ; Vol. 22, No. 4. pp. 381-390.
@article{ee2c2ed0cba84b6296020c4df1a1887e,
title = "Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress",
abstract = "The influence on central hemodynamics of enflurane, in uniform anesthetic concentration (1.5 MAC), was studied in 10 normocapnic patients undergoing upper abdominal surgery. The patients were studied awake, during anesthesia prior to surgery, and during surgery. On institution of anesthesia, cardiac output (Q̇T) fell from 5.05 ± 0.51 to 4.12 ± 0.15 l/min and systemic vascular resistance (SVR) decreased from 2.36 ± 0.22 to 1.93 ± 0.18 kPa.min.l-3. The arteriovenous oxygen content difference (AVD) did not change. On commencement of surgery, AVD diminished from 38.5 ± 2.6 to 30.8 ± 1.9 ml/min and Q̇T rose to 5.82 ± 0.46 l/min, while SVR remained unchanged. It is concluded that the fall in Q̇T seen during enflurane anesthesia is caused by a diminished tissue oxygen demand. It is also suggested that enflurane acts as an α-blocking agent.",
author = "J. Santesson and L. Irestedt and Per-Olof J{\"a}rnberg and O. Norlander",
year = "1978",
language = "English (US)",
volume = "22",
pages = "381--390",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress

AU - Santesson, J.

AU - Irestedt, L.

AU - Järnberg, Per-Olof

AU - Norlander, O.

PY - 1978

Y1 - 1978

N2 - The influence on central hemodynamics of enflurane, in uniform anesthetic concentration (1.5 MAC), was studied in 10 normocapnic patients undergoing upper abdominal surgery. The patients were studied awake, during anesthesia prior to surgery, and during surgery. On institution of anesthesia, cardiac output (Q̇T) fell from 5.05 ± 0.51 to 4.12 ± 0.15 l/min and systemic vascular resistance (SVR) decreased from 2.36 ± 0.22 to 1.93 ± 0.18 kPa.min.l-3. The arteriovenous oxygen content difference (AVD) did not change. On commencement of surgery, AVD diminished from 38.5 ± 2.6 to 30.8 ± 1.9 ml/min and Q̇T rose to 5.82 ± 0.46 l/min, while SVR remained unchanged. It is concluded that the fall in Q̇T seen during enflurane anesthesia is caused by a diminished tissue oxygen demand. It is also suggested that enflurane acts as an α-blocking agent.

AB - The influence on central hemodynamics of enflurane, in uniform anesthetic concentration (1.5 MAC), was studied in 10 normocapnic patients undergoing upper abdominal surgery. The patients were studied awake, during anesthesia prior to surgery, and during surgery. On institution of anesthesia, cardiac output (Q̇T) fell from 5.05 ± 0.51 to 4.12 ± 0.15 l/min and systemic vascular resistance (SVR) decreased from 2.36 ± 0.22 to 1.93 ± 0.18 kPa.min.l-3. The arteriovenous oxygen content difference (AVD) did not change. On commencement of surgery, AVD diminished from 38.5 ± 2.6 to 30.8 ± 1.9 ml/min and Q̇T rose to 5.82 ± 0.46 l/min, while SVR remained unchanged. It is concluded that the fall in Q̇T seen during enflurane anesthesia is caused by a diminished tissue oxygen demand. It is also suggested that enflurane acts as an α-blocking agent.

UR - http://www.scopus.com/inward/record.url?scp=0017822426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017822426&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 381

EP - 390

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 4

ER -