Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content

E. S. Krul, S. L. Lemke, R. Mukherjea, M. L. Taylor, D. A. Goldstein, H. Su, P. Liu, A. Lawless, William Harris, K. C. Maki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: The purpose of this randomized, controlled, parallel group study was to characterize the relationships between dosages of stearidonic acid (SDA) and eicosapentaenoic acid (EPA), and incorporation of EPA into red blood cell (RBC) membranes over time. Methods: Healthy subjects (n=131) received capsules with placebo (safflower oil), SDA (0.43, 1.3, 2.6, or 5.2. g/d) or EPA (0.44, 1.3, or 2.7. g/d) for 12 weeks. RBC fatty acids were analyzed biweekly. Results: RBC %EPA increased in all EPA and SDA groups (p

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume86
Issue number1-2
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

lissamine rhodamine B
Eicosapentaenoic Acid
Blood
Erythrocytes
Cells
Safflower Oil
Therapeutics
Cell membranes
Capsules
Healthy Volunteers
Fatty Acids
Placebos
Cell Membrane
stearidonic acid

Keywords

  • Dosage-response
  • Eicosapentaenoic acid
  • Omega-3 fatty acids
  • RBC
  • Stearidonic acid

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

Cite this

Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content. / Krul, E. S.; Lemke, S. L.; Mukherjea, R.; Taylor, M. L.; Goldstein, D. A.; Su, H.; Liu, P.; Lawless, A.; Harris, William; Maki, K. C.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 86, No. 1-2, 01.2012, p. 51-59.

Research output: Contribution to journalArticle

Krul, E. S. ; Lemke, S. L. ; Mukherjea, R. ; Taylor, M. L. ; Goldstein, D. A. ; Su, H. ; Liu, P. ; Lawless, A. ; Harris, William ; Maki, K. C. / Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2012 ; Vol. 86, No. 1-2. pp. 51-59.
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abstract = "Objective: The purpose of this randomized, controlled, parallel group study was to characterize the relationships between dosages of stearidonic acid (SDA) and eicosapentaenoic acid (EPA), and incorporation of EPA into red blood cell (RBC) membranes over time. Methods: Healthy subjects (n=131) received capsules with placebo (safflower oil), SDA (0.43, 1.3, 2.6, or 5.2. g/d) or EPA (0.44, 1.3, or 2.7. g/d) for 12 weeks. RBC fatty acids were analyzed biweekly. Results: RBC {\%}EPA increased in all EPA and SDA groups (p",
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AU - Krul, E. S.

AU - Lemke, S. L.

AU - Mukherjea, R.

AU - Taylor, M. L.

AU - Goldstein, D. A.

AU - Su, H.

AU - Liu, P.

AU - Lawless, A.

AU - Harris, William

AU - Maki, K. C.

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KW - Eicosapentaenoic acid

KW - Omega-3 fatty acids

KW - RBC

KW - Stearidonic acid

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