Effects of dimethyl sulfoxide on ocular inflammation

C. Hanna, Frederick (Fritz) Fraunfelder, S. M. Meyer

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The anti inflammatory properties of topical ocular dimethyl sulfoxide (DMSO) were investigated using a standard experimental model of an acute inflammatory ocular inflammation. Ninety percent and 100% DMSO aggravated the inflammatory response, 50% to 70% DMSO had similar responses as the control eye; however, 30% DMSO had definite anti inflammatory properties. Dexamethasone 0.1% was superior to 30% DMSO as an anti inflammatory agent. From this study it is evident that high concentrations of DMSO are irritating to the inflammatory ocular model used while lower concentrations have anti inflammatory properties. The two side effects of skin irritation at the site of application and breath odor may be the subjective influence that leads certain patients to report a beneficial effect of DMSO treatment in ocular inflammation.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalAnnals of Ophthalmology
Volume9
Issue number1
Publication statusPublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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