Effects of Different Mixing Agents on the Stability of Sodium Tetradecyl Sulfate (STS) Foam: An Experimental Study

Kazuki Hashimoto; Barry Uchida; Masahiro Horikawa; Hidefumi Mimura; Khashayar Farsad

doi:10.1007/s00270-018-2049-2

Effects of Different Mixing Agents on the Stability of Sodium Tetradecyl Sulfate (STS) Foam: An Experimental Study

Kazuki Hashimoto, Barry Uchida, Masahiro Horikawa, Hidefumi Mimura, Khashayar Farsad

Dotter Institute

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To evaluate the effect of air, CO₂ and contrast medium-air on the dwell time (DT) stability of sodium tetradecyl sulfate (STS) foam. Materials and Methods: Three types of foam sclerosants (air-foam, CO₂-foam, contrast-air-foam) were injected eight times into an inclined straight plastic tube (internal diameters 4 mm and 10 mm) filled with a blood substitute. Injections were captured by CCD camera, and images were transferred for digital analysis and calculation of DT. Results: Contrast-air-foam and air-foam in a 4-mm tube showed 5.6-/3.3-fold greater DT compared to CO₂-foam, respectively (P = 0.001). Contrast-air-foam in a 10-mm tube showed 2.1-fold greater DT compared to CO₂-foam (P = 0.0167). Conclusion: A mixture of air and iodinated contrast improves the stability of STS foam compared to mixtures using only air or CO₂. Further, animal and clinical studies are needed to validate this in vitro result.

Original language	English (US)
Pages (from-to)	1952-1957
Number of pages	6
Journal	Cardiovascular and interventional radiology
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s00270-018-2049-2
State	Published - Dec 1 2018

Keywords

Fibro-vein
Foam sclerotherapy
Lower extremity varix
Polidocanol
Sodium tetradecyl sulfate (STS)
Sotradecol
Venous malformation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s00270-018-2049-2

Cite this

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title = "Effects of Different Mixing Agents on the Stability of Sodium Tetradecyl Sulfate (STS) Foam: An Experimental Study",

abstract = "Purpose: To evaluate the effect of air, CO2 and contrast medium-air on the dwell time (DT) stability of sodium tetradecyl sulfate (STS) foam. Materials and Methods: Three types of foam sclerosants (air-foam, CO2-foam, contrast-air-foam) were injected eight times into an inclined straight plastic tube (internal diameters 4 mm and 10 mm) filled with a blood substitute. Injections were captured by CCD camera, and images were transferred for digital analysis and calculation of DT. Results: Contrast-air-foam and air-foam in a 4-mm tube showed 5.6-/3.3-fold greater DT compared to CO2-foam, respectively (P = 0.001). Contrast-air-foam in a 10-mm tube showed 2.1-fold greater DT compared to CO2-foam (P = 0.0167). Conclusion: A mixture of air and iodinated contrast improves the stability of STS foam compared to mixtures using only air or CO2. Further, animal and clinical studies are needed to validate this in vitro result.",

keywords = "Fibro-vein, Foam sclerotherapy, Lower extremity varix, Polidocanol, Sodium tetradecyl sulfate (STS), Sotradecol, Venous malformation",

author = "Kazuki Hashimoto and Barry Uchida and Masahiro Horikawa and Hidefumi Mimura and Khashayar Farsad",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).",

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AU - Horikawa, Masahiro

AU - Mimura, Hidefumi

AU - Farsad, Khashayar

PY - 2018/12/1

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N2 - Purpose: To evaluate the effect of air, CO2 and contrast medium-air on the dwell time (DT) stability of sodium tetradecyl sulfate (STS) foam. Materials and Methods: Three types of foam sclerosants (air-foam, CO2-foam, contrast-air-foam) were injected eight times into an inclined straight plastic tube (internal diameters 4 mm and 10 mm) filled with a blood substitute. Injections were captured by CCD camera, and images were transferred for digital analysis and calculation of DT. Results: Contrast-air-foam and air-foam in a 4-mm tube showed 5.6-/3.3-fold greater DT compared to CO2-foam, respectively (P = 0.001). Contrast-air-foam in a 10-mm tube showed 2.1-fold greater DT compared to CO2-foam (P = 0.0167). Conclusion: A mixture of air and iodinated contrast improves the stability of STS foam compared to mixtures using only air or CO2. Further, animal and clinical studies are needed to validate this in vitro result.

AB - Purpose: To evaluate the effect of air, CO2 and contrast medium-air on the dwell time (DT) stability of sodium tetradecyl sulfate (STS) foam. Materials and Methods: Three types of foam sclerosants (air-foam, CO2-foam, contrast-air-foam) were injected eight times into an inclined straight plastic tube (internal diameters 4 mm and 10 mm) filled with a blood substitute. Injections were captured by CCD camera, and images were transferred for digital analysis and calculation of DT. Results: Contrast-air-foam and air-foam in a 4-mm tube showed 5.6-/3.3-fold greater DT compared to CO2-foam, respectively (P = 0.001). Contrast-air-foam in a 10-mm tube showed 2.1-fold greater DT compared to CO2-foam (P = 0.0167). Conclusion: A mixture of air and iodinated contrast improves the stability of STS foam compared to mixtures using only air or CO2. Further, animal and clinical studies are needed to validate this in vitro result.

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KW - Foam sclerotherapy

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KW - Sotradecol

KW - Venous malformation

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Effects of Different Mixing Agents on the Stability of Sodium Tetradecyl Sulfate (STS) Foam: An Experimental Study

Abstract

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