Effects of diethylpropion and d-amphetamine after subcutaneous and oral administration

Donald R. Jasinski, John G. Nutt, John D. Griffith

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The effects of diethylpropion were determined and compared with those of d-amphetamine in 9 subjects using a crossover design. Diethylpropion produced effects qualitatively similar to those of d-amphetamine, but significantly less potent. Orally diethylpropion was 1 6 to 1 11 as potent as d-amphetamine while subcutaneously diethylpropion was 1 10 to 1 20 as potent as d-amphetamine. A striking difference between diethylpropion and d-amphetamine was the relatively greater oral efficacy of diethylpropion. Diethylpropion was twice as potent orally as subcutaneously while oral and subcutaneous d-amphetamine were equipotent.

Original languageEnglish (US)
Pages (from-to)645-652
Number of pages8
JournalClinical pharmacology and therapeutics
Issue number4
StatePublished - Oct 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


Dive into the research topics of 'Effects of diethylpropion and d-amphetamine after subcutaneous and oral administration'. Together they form a unique fingerprint.

Cite this