The effects of diethylpropion were determined and compared with those of d-amphetamine in 9 subjects using a crossover design. Diethylpropion produced effects qualitatively similar to those of d-amphetamine, but significantly less potent. Orally diethylpropion was 1 6 to 1 11 as potent as d-amphetamine while subcutaneously diethylpropion was 1 10 to 1 20 as potent as d-amphetamine. A striking difference between diethylpropion and d-amphetamine was the relatively greater oral efficacy of diethylpropion. Diethylpropion was twice as potent orally as subcutaneously while oral and subcutaneous d-amphetamine were equipotent.
ASJC Scopus subject areas
- Pharmacology (medical)