Effects of diethylpropion and d-amphetamine after subcutaneous and oral administration

Donald R. Jasinski, John Nutt, John D. Griffith

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Abstract

The effects of diethylpropion were determined and compared with those of d-amphetamine in 9 subjects using a crossover design. Diethylpropion produced effects qualitatively similar to those of d-amphetamine, but significantly less potent. Orally diethylpropion was 1 6 to 1 11 as potent as d-amphetamine while subcutaneously diethylpropion was 1 10 to 1 20 as potent as d-amphetamine. A striking difference between diethylpropion and d-amphetamine was the relatively greater oral efficacy of diethylpropion. Diethylpropion was twice as potent orally as subcutaneously while oral and subcutaneous d-amphetamine were equipotent.

Original languageEnglish (US)
Pages (from-to)645-652
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume16
Issue number4
Publication statusPublished - Oct 1974
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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