Effects of [Des-Tyr1]-γ-endorphin and α-endorphin on substantia nigra self-stimulation

Daniel Dorsa, Jan M. Van Ree, David De Wied

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The β-lipotropin fragments, [des-Tyr1]-γ-endorphin (DTγE, β-LPH62-77) and α-endorphin (β-LPH61-76) affect self-stimulating behavior associated with electrical stimulation of neurons of the ventral tegmentum area of rats in an opposite way. Subcutaneous administration of DTγE (5 and 25 μg) attenuated and that of α-endorphin (5 and 25 μg) facilitated this behavior. Similar opposite effects were observed after subcutaneous treatment with respectively the neuroleptic haloperidol (5 μg) and the psychostimulant amphetamine (100 μg). By using a biphasic testparadigm of decreasing and subsequent increasing the stimulating current intensity it was noted that the neuropeptides predominantly exerted their effect on responding at current intensities in the neighbourhood of the threshold for eliciting the behavior, whereas the neuroleptic and psychostimulant drug appeared to affect responding at currents associated with maximal performance as well. In contrast to haloperidol, the effectiveness of DTγE was of a long term nature, in that performance of the rat was still affected 24 hr after peptide treatment. The results support the hypothesis that DTγE in some aspects interacts with brain substrates in a way comparable to that of neuroleptics. The data further suggest that closely related fragments of β-lipotropin modulate on-going activity of in particular dopaminergic neuronal systems.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume10
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Endorphins
Self Stimulation
Substantia Nigra
beta-Lipotropin
Antipsychotic Agents
Haloperidol
Rats
Amphetamine
Neuropeptides
Electric Stimulation
Neurons
Brain
Peptides
Substrates
Therapeutics

Keywords

  • Amphetamine
  • Dopamine
  • Haloperidol
  • Intracranial self-stimulation
  • Substantia nigra
  • [Des-Tyr]-γ-endorphin
  • α-Endorphin
  • β-Endorphin fragments

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of [Des-Tyr1]-γ-endorphin and α-endorphin on substantia nigra self-stimulation. / Dorsa, Daniel; Van Ree, Jan M.; De Wied, David.

In: Pharmacology, Biochemistry and Behavior, Vol. 10, No. 6, 1979, p. 899-905.

Research output: Contribution to journalArticle

@article{650f3168dc6a4720951f6ed3287a397b,
title = "Effects of [Des-Tyr1]-γ-endorphin and α-endorphin on substantia nigra self-stimulation",
abstract = "The β-lipotropin fragments, [des-Tyr1]-γ-endorphin (DTγE, β-LPH62-77) and α-endorphin (β-LPH61-76) affect self-stimulating behavior associated with electrical stimulation of neurons of the ventral tegmentum area of rats in an opposite way. Subcutaneous administration of DTγE (5 and 25 μg) attenuated and that of α-endorphin (5 and 25 μg) facilitated this behavior. Similar opposite effects were observed after subcutaneous treatment with respectively the neuroleptic haloperidol (5 μg) and the psychostimulant amphetamine (100 μg). By using a biphasic testparadigm of decreasing and subsequent increasing the stimulating current intensity it was noted that the neuropeptides predominantly exerted their effect on responding at current intensities in the neighbourhood of the threshold for eliciting the behavior, whereas the neuroleptic and psychostimulant drug appeared to affect responding at currents associated with maximal performance as well. In contrast to haloperidol, the effectiveness of DTγE was of a long term nature, in that performance of the rat was still affected 24 hr after peptide treatment. The results support the hypothesis that DTγE in some aspects interacts with brain substrates in a way comparable to that of neuroleptics. The data further suggest that closely related fragments of β-lipotropin modulate on-going activity of in particular dopaminergic neuronal systems.",
keywords = "Amphetamine, Dopamine, Haloperidol, Intracranial self-stimulation, Substantia nigra, [Des-Tyr]-γ-endorphin, α-Endorphin, β-Endorphin fragments",
author = "Daniel Dorsa and {Van Ree}, {Jan M.} and {De Wied}, David",
year = "1979",
doi = "10.1016/0091-3057(79)90065-0",
language = "English (US)",
volume = "10",
pages = "899--905",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Effects of [Des-Tyr1]-γ-endorphin and α-endorphin on substantia nigra self-stimulation

AU - Dorsa, Daniel

AU - Van Ree, Jan M.

AU - De Wied, David

PY - 1979

Y1 - 1979

N2 - The β-lipotropin fragments, [des-Tyr1]-γ-endorphin (DTγE, β-LPH62-77) and α-endorphin (β-LPH61-76) affect self-stimulating behavior associated with electrical stimulation of neurons of the ventral tegmentum area of rats in an opposite way. Subcutaneous administration of DTγE (5 and 25 μg) attenuated and that of α-endorphin (5 and 25 μg) facilitated this behavior. Similar opposite effects were observed after subcutaneous treatment with respectively the neuroleptic haloperidol (5 μg) and the psychostimulant amphetamine (100 μg). By using a biphasic testparadigm of decreasing and subsequent increasing the stimulating current intensity it was noted that the neuropeptides predominantly exerted their effect on responding at current intensities in the neighbourhood of the threshold for eliciting the behavior, whereas the neuroleptic and psychostimulant drug appeared to affect responding at currents associated with maximal performance as well. In contrast to haloperidol, the effectiveness of DTγE was of a long term nature, in that performance of the rat was still affected 24 hr after peptide treatment. The results support the hypothesis that DTγE in some aspects interacts with brain substrates in a way comparable to that of neuroleptics. The data further suggest that closely related fragments of β-lipotropin modulate on-going activity of in particular dopaminergic neuronal systems.

AB - The β-lipotropin fragments, [des-Tyr1]-γ-endorphin (DTγE, β-LPH62-77) and α-endorphin (β-LPH61-76) affect self-stimulating behavior associated with electrical stimulation of neurons of the ventral tegmentum area of rats in an opposite way. Subcutaneous administration of DTγE (5 and 25 μg) attenuated and that of α-endorphin (5 and 25 μg) facilitated this behavior. Similar opposite effects were observed after subcutaneous treatment with respectively the neuroleptic haloperidol (5 μg) and the psychostimulant amphetamine (100 μg). By using a biphasic testparadigm of decreasing and subsequent increasing the stimulating current intensity it was noted that the neuropeptides predominantly exerted their effect on responding at current intensities in the neighbourhood of the threshold for eliciting the behavior, whereas the neuroleptic and psychostimulant drug appeared to affect responding at currents associated with maximal performance as well. In contrast to haloperidol, the effectiveness of DTγE was of a long term nature, in that performance of the rat was still affected 24 hr after peptide treatment. The results support the hypothesis that DTγE in some aspects interacts with brain substrates in a way comparable to that of neuroleptics. The data further suggest that closely related fragments of β-lipotropin modulate on-going activity of in particular dopaminergic neuronal systems.

KW - Amphetamine

KW - Dopamine

KW - Haloperidol

KW - Intracranial self-stimulation

KW - Substantia nigra

KW - [Des-Tyr]-γ-endorphin

KW - α-Endorphin

KW - β-Endorphin fragments

UR - http://www.scopus.com/inward/record.url?scp=0018718837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018718837&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(79)90065-0

DO - 10.1016/0091-3057(79)90065-0

M3 - Article

C2 - 482311

AN - SCOPUS:0018718837

VL - 10

SP - 899

EP - 905

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 6

ER -