Effects of denervation on laryngeal muscles: A canine model

Maisie Shindo, Garrett D. Herzon, David G. Hanson, Donald J. Cain, Vinod Sahgal

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The purpose of this study was to chronologically evaluate the changes in function and histomorphom-etry of denervated laryngeal muscles. In 14 adult mongrel dogs, a 2.5-cm segment of the right recurrent laryngeal nerve was excised. Videolaryngoscopy and electromyography were performed at 1, 2, 3, 4, 5, 6, and 9 months under intravenous sedation. The animals were then killed, and the laryngeal muscles were processed for histochemical reactions. The mean muscle fiber diameter, standard deviation, and muscle fiber type composition were determined. The findings indicate that, following recurrent laryngeal nerve sectioning, the canine intrinsic laryngeal muscles undergo denervation atrophy for approximately 3 months, after which reinnervation occurs. The source of reinnervation appears to be from regenerated nerve fibers of the sectioned recurrent laryngeal nerve. The nerve fibers nonselectively reinner-vated the abductor and adductor muscles of the larynx.

Original languageEnglish (US)
Pages (from-to)663-669
Number of pages7
JournalLaryngoscope
Volume102
Issue number6
StatePublished - 1992
Externally publishedYes

Fingerprint

Laryngeal Muscles
Recurrent Laryngeal Nerve
Denervation
Canidae
Nerve Fibers
Muscles
Muscle Denervation
Electromyography
Larynx
Atrophy
Dogs

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Shindo, M., Herzon, G. D., Hanson, D. G., Cain, D. J., & Sahgal, V. (1992). Effects of denervation on laryngeal muscles: A canine model. Laryngoscope, 102(6), 663-669.

Effects of denervation on laryngeal muscles : A canine model. / Shindo, Maisie; Herzon, Garrett D.; Hanson, David G.; Cain, Donald J.; Sahgal, Vinod.

In: Laryngoscope, Vol. 102, No. 6, 1992, p. 663-669.

Research output: Contribution to journalArticle

Shindo, M, Herzon, GD, Hanson, DG, Cain, DJ & Sahgal, V 1992, 'Effects of denervation on laryngeal muscles: A canine model', Laryngoscope, vol. 102, no. 6, pp. 663-669.
Shindo M, Herzon GD, Hanson DG, Cain DJ, Sahgal V. Effects of denervation on laryngeal muscles: A canine model. Laryngoscope. 1992;102(6):663-669.
Shindo, Maisie ; Herzon, Garrett D. ; Hanson, David G. ; Cain, Donald J. ; Sahgal, Vinod. / Effects of denervation on laryngeal muscles : A canine model. In: Laryngoscope. 1992 ; Vol. 102, No. 6. pp. 663-669.
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