TY - JOUR
T1 - Effects of denervation on laryngeal muscles
T2 - A canine model
AU - Shindo, Maisie L.
AU - Herzon, Garrett D.
AU - Hanson, David G.
AU - Cain, Donald J.
AU - Sahgal, Vinod
PY - 1992/6
Y1 - 1992/6
N2 - The purpose of this study was to chronologically evaluate the changes in function and histomorphom-etry of denervated laryngeal muscles. In 14 adult mongrel dogs, a 2.5-cm segment of the right recurrent laryngeal nerve was excised. Videolaryngoscopy and electromyography were performed at 1, 2, 3, 4, 5, 6, and 9 months under intravenous sedation. The animals were then killed, and the laryngeal muscles were processed for histochemical reactions. The mean muscle fiber diameter, standard deviation, and muscle fiber type composition were determined. The findings indicate that, following recurrent laryngeal nerve sectioning, the canine intrinsic laryngeal muscles undergo denervation atrophy for approximately 3 months, after which reinnervation occurs. The source of reinnervation appears to be from regenerated nerve fibers of the sectioned recurrent laryngeal nerve. The nerve fibers nonselectively reinner-vated the abductor and adductor muscles of the larynx.
AB - The purpose of this study was to chronologically evaluate the changes in function and histomorphom-etry of denervated laryngeal muscles. In 14 adult mongrel dogs, a 2.5-cm segment of the right recurrent laryngeal nerve was excised. Videolaryngoscopy and electromyography were performed at 1, 2, 3, 4, 5, 6, and 9 months under intravenous sedation. The animals were then killed, and the laryngeal muscles were processed for histochemical reactions. The mean muscle fiber diameter, standard deviation, and muscle fiber type composition were determined. The findings indicate that, following recurrent laryngeal nerve sectioning, the canine intrinsic laryngeal muscles undergo denervation atrophy for approximately 3 months, after which reinnervation occurs. The source of reinnervation appears to be from regenerated nerve fibers of the sectioned recurrent laryngeal nerve. The nerve fibers nonselectively reinner-vated the abductor and adductor muscles of the larynx.
UR - http://www.scopus.com/inward/record.url?scp=0026680797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026680797&partnerID=8YFLogxK
U2 - 10.1288/00005537-199206000-00012
DO - 10.1288/00005537-199206000-00012
M3 - Article
C2 - 1534862
AN - SCOPUS:0026680797
SN - 0023-852X
VL - 102
SP - 663
EP - 669
JO - Laryngoscope
JF - Laryngoscope
IS - 6
ER -