Effects of colesevelam HCl on sterol and bile acid excretion in patients with type IIa hypercholesterolemia

J. M. Donovan, K. Von Bergmann, K. D.R. Setchell, J. Isaacsohn, A. S. Pappu, D. R. Illingworth, T. Olson, S. K. Burke

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Colesevelam HCl is a potent bile acid-binding polymer. This study's aim was to determine effects of colesevelam HCl on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Twenty-four patients (low-density lipoprotein cholesterol, 130 to 220 mg/dL) enrolled in an open-label, parallel-design study, entered an American Heart Association/National Cholesterol Education Program diet for 6 weeks and were randomized to colesevelam HCl, 2.3 or 3.8 g/day for 4 weeks. In an apparent dose-related manner, respective mean serum concentrations HCl of low-density lipoprotein cholesterol decreased by 10% (P < 0.01) and 13% (P = 0.05), mean total cholesterol levels decreased by 4.9% (P = 0.05) and 6.1% (P = 0.09), and total fecal bile acid excretion showed median changes of +324% (P < 0.05) and +316% (P < 0.05). Colesevelam HCl did not affect fecal neutral sterol or fecal fatty acid excretion; however, 24-hr urinary mevalonic acid levels significantly increased in both treatment groups (P < 0.05). The cholesterol-lowering action of colesevelam HCl appears to be mediated through increased bile acid excretion.

Original languageEnglish (US)
Pages (from-to)1232-1238
Number of pages7
JournalDigestive diseases and sciences
Volume50
Issue number7
DOIs
StatePublished - Jul 1 2005

Keywords

  • Bile acid sequestrant
  • Cholesterol
  • Colesevelam
  • Hypercholesterolemia
  • Low-density lipoprotein

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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    Donovan, J. M., Von Bergmann, K., Setchell, K. D. R., Isaacsohn, J., Pappu, A. S., Illingworth, D. R., Olson, T., & Burke, S. K. (2005). Effects of colesevelam HCl on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Digestive diseases and sciences, 50(7), 1232-1238. https://doi.org/10.1007/s10620-005-2765-8