Effects of chronic cocaine abuse on postsynaptic dopamine receptors

Nora D. Volkow; Joanna S. Fowler; Alfred P. Wolf; David Schlyer; Chyng Yann Shiue; Robert Alpert; Stephen L. Dewey; Jean Logan; Bernard Bendriem; David Christman; Robert Hitzemann; Fritz Henn

Effects of chronic cocaine abuse on postsynaptic dopamine receptors

Nora D. Volkow, Joanna S. Fowler, Alfred P. Wolf, David Schlyer, Chyng Yann Shiue, Robert Alpert, Stephen L. Dewey, Jean Logan, Bernard Bendriem, David Christman, Robert Hitzemann, Fritz Henn

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [¹⁸F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [¹⁸F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.

Original language	English (US)
Pages (from-to)	97-104
Number of pages	8
Journal	Annual Review of Addictions Research and Treatment
Volume	2
Issue number	C
State	Published - Dec 1 1992

ASJC Scopus subject areas

Medicine (miscellaneous)

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Effects of chronic cocaine abuse on postsynaptic dopamine receptors. / Volkow, Nora D.; Fowler, Joanna S.; Wolf, Alfred P.; Schlyer, David; Shiue, Chyng Yann; Alpert, Robert; Dewey, Stephen L.; Logan, Jean; Bendriem, Bernard; Christman, David; Hitzemann, Robert; Henn, Fritz.

In: Annual Review of Addictions Research and Treatment, Vol. 2, No. C, 01.12.1992, p. 97-104.

Research output: Contribution to journal › Article › peer-review

Volkow, Nora D. ; Fowler, Joanna S. ; Wolf, Alfred P. ; Schlyer, David ; Shiue, Chyng Yann ; Alpert, Robert ; Dewey, Stephen L. ; Logan, Jean ; Bendriem, Bernard ; Christman, David ; Hitzemann, Robert ; Henn, Fritz. / Effects of chronic cocaine abuse on postsynaptic dopamine receptors. In: Annual Review of Addictions Research and Treatment. 1992 ; Vol. 2, No. C. pp. 97-104.

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