Abstract
To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-104 |
| Number of pages | 8 |
| Journal | Annual Review of Addictions Research and Treatment |
| Volume | 2 |
| Issue number | C |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
Effects of chronic cocaine abuse on postsynaptic dopamine receptors. / Volkow, Nora D.; Fowler, Joanna S.; Wolf, Alfred P.; Schlyer, David; Shiue, Chyng Yann; Alpert, Robert; Dewey, Stephen L.; Logan, Jean; Bendriem, Bernard; Christman, David; Hitzemann, Robert; Henn, Fritz.
In: Annual Review of Addictions Research and Treatment, Vol. 2, No. C, 1992, p. 97-104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of chronic cocaine abuse on postsynaptic dopamine receptors
AU - Volkow, Nora D.
AU - Fowler, Joanna S.
AU - Wolf, Alfred P.
AU - Schlyer, David
AU - Shiue, Chyng Yann
AU - Alpert, Robert
AU - Dewey, Stephen L.
AU - Logan, Jean
AU - Bendriem, Bernard
AU - Christman, David
AU - Hitzemann, Robert
AU - Henn, Fritz
PY - 1992
Y1 - 1992
N2 - To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
AB - To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
UR - http://www.scopus.com/inward/record.url?scp=0027000641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027000641&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027000641
VL - 2
SP - 97
EP - 104
JO - Annual Review of Addictions Research and Treatment
JF - Annual Review of Addictions Research and Treatment
SN - 0955-663X
IS - C
ER -