Effects of catechol estrogen infusions upon gonadotropin and prolactin concentrations in men

George R. Merriam, Shinzo Kono, Harry R. Keiser, D. Lynn Loriaux, Mortimer B. Lipsett

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

To study the effects of catechol estrogens upon gonadotropin secretion, 2-hydroxyestrone (2-OHE1) and 2-hydroxyestradiol (2-OHE2) were administered iv to young adult men in a range of doses for 4 days. Blood samples were obtained for plasma LH, FSH, and PRL at 20-min intervals for 6 h before and at the end of the infusion period. 2-OHE1 had no effect upon gonadotropins or PRL in doses up to 1.6 mg/day; at 3.2 and 6.6 mg/day, it produced a slight suppression of LH and FSH, with no change in PRL. 2-OHE2 was generally ineffective at 100 μg/ day, but doses from 200-800 μg/day supressed gonadotropins, without changes in PRL. These infusions elevated 2-OHE1 and 2-OHE2 plasma levels to values comparable to those measured in late pregnancy. There were no associated effects upon blood pressure and only minimal changes in urinary catecholamine excretion. No effects that could be interpreted as antiestrogenic were observed. These results are consistent with the hypothesis that circulating catechol estrogens behave as weak estrogens in men.

Original languageEnglish (US)
Pages (from-to)784-789
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume53
Issue number4
DOIs
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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