Effects of cardiac resynchronization therapy on ventricular remodeling

Hind Rahmouni, James N. Kirkpatrick, Martin G. John Sutton

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Remodeling reflects the structural and functional deterioration that occurs in heart failure. Indices of remodeling constitute an important marker of the severity of heart failure, and reverse remodeling is an accepted goal in the treatment of heart failure. Cardiac resynchronization therapy (CRT) has been shown to reverse the remodeling process by improving ventricular size, shape, and mass and reducing mitral regurgitation in the short and long term. Diastolic function, right ventricular size, and atria exhibit reverse remodeling. Trials of medical therapy for heart failure strongly link remodeling indices with outcomes, and emerging data suggest that remodeling indices may be among the most accurate predictors of long-term morbidity and mortality in heart failure patients with CRT devices. This review discusses remodeling and focuses on the evidence for CRT-induced reverse remodeling.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalCurrent Heart Failure Reports
Volume5
Issue number1
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Cardiac Resynchronization Therapy
Ventricular Remodeling
Heart Failure
Cardiac Resynchronization Therapy Devices
Right Ventricular Function
Mitral Valve Insufficiency
Treatment Failure
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency Medicine
  • Physiology (medical)

Cite this

Effects of cardiac resynchronization therapy on ventricular remodeling. / Rahmouni, Hind; Kirkpatrick, James N.; John Sutton, Martin G.

In: Current Heart Failure Reports, Vol. 5, No. 1, 2008, p. 25-30.

Research output: Contribution to journalReview article

Rahmouni, Hind ; Kirkpatrick, James N. ; John Sutton, Martin G. / Effects of cardiac resynchronization therapy on ventricular remodeling. In: Current Heart Failure Reports. 2008 ; Vol. 5, No. 1. pp. 25-30.
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