Effects of Aromatase Inhibition and Androgen Activity on Serotonin and Behavior in Male Macaques

Cynthia Bethea, Arubala Reddy, Nicola Robertson, Kristine Coleman

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Aggression in humans and animals has been linked to androgens and serotonin function. To further our understanding of the effect of androgens on serotonin and aggression in male macaques, we sought to manipulate circulating androgens and the activity of aromatase; and to then determine behavior and the endogenous availability of serotonin. Male Japanese macaques (Macaca fuscata) were castrated for 5-7 months and then treated for 3 months with (a) placebo; (b) testosterone (T); (c) T Dutasteride (5a reductase inhibitor; AvodartTM); (d) T Letrozole (nonsteroidal aromatase inhibitor; FemeraTM); (e) Flutamide ATD (androgen antagonist plus steroidal aromatase inhibitor); or (f) dihydrotestosterone (DHT) ATD (n 5/group). Behavioral observations were made during treatments. At the end of the treatment period, each animal was sedated with propofol and administered a bolus of fenfluramine (5 mg/kg). Fenfluramine causes the release of serotonin proportional to endogenous availability and in turn, serotonin stimulates the secretion of prolactin. Therefore, serum prolactin concentrations reflect endogenous serotonin. Fenfluramine significantly increased serotonin/prolactin in all groups (p 2 0.95). In summary, androgens induced aggressive behavior but they did not regulate serotonin. Altogether, the data suggest that aromatase activity supports serotonin production and that androgens increase aggression by another mechanism.

    Original languageEnglish (US)
    Pages (from-to)400-414
    Number of pages15
    JournalBehavioral Neuroscience
    Volume127
    Issue number3
    DOIs
    StatePublished - Jun 2013

    Fingerprint

    Aromatase
    Macaca
    Androgens
    Serotonin
    Fenfluramine
    Aggression
    Prolactin
    Aromatase Inhibitors
    letrozole
    Flutamide
    Inhibition (Psychology)
    Androgen Antagonists
    Dihydrotestosterone
    Propofol
    Testosterone
    Oxidoreductases
    Placebos

    Keywords

    • Aggression
    • Androgen
    • Aromatase
    • Fenfluramine
    • Serotonin

    ASJC Scopus subject areas

    • Behavioral Neuroscience

    Cite this

    Effects of Aromatase Inhibition and Androgen Activity on Serotonin and Behavior in Male Macaques. / Bethea, Cynthia; Reddy, Arubala; Robertson, Nicola; Coleman, Kristine.

    In: Behavioral Neuroscience, Vol. 127, No. 3, 06.2013, p. 400-414.

    Research output: Contribution to journalArticle

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