Effects of alcohol on c-Myc protein in the brain

Tunde Akinyeke, Sydney J. Weber, April T. Davenport, Erich J. Baker, James B. Daunais, Jacob Raber

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Alcoholism is a disorder categorized by significant impairment that is directly related to persistent and extreme use of alcohol. The effects of alcoholism on c-Myc protein expression in the brain have been scarcely studied. This is the first study to investigate the role different characteristics of alcoholism have on c-Myc protein in the brain. We analyzed c-Myc protein in the hypothalamus and amygdala from five different animal models of alcohol abuse. c-Myc protein was increased following acute ethanol exposure in a mouse knockout model and following chronic ethanol consumption in vervet monkeys. We also observed increases in c-Myc protein exposure in animals that are genetically predisposed to alcohol and methamphetamine abuse. Lastly, c-Myc protein was increased in animals that were acutely exposed to methamphetamine when compared to control treated animals. These results suggest that in substance abuse c-Myc plays an important role in the brain's response.

Original languageEnglish (US)
JournalBehavioural Brain Research
DOIs
StateAccepted/In press - Aug 1 2016

Keywords

  • Alcoholism
  • C-Myc
  • Phosphorylation
  • Preference
  • Withdrawal

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Akinyeke, T., Weber, S. J., Davenport, A. T., Baker, E. J., Daunais, J. B., & Raber, J. (Accepted/In press). Effects of alcohol on c-Myc protein in the brain. Behavioural Brain Research. https://doi.org/10.1016/j.bbr.2016.11.009