Effects of aging on the renal glomerulus

Sharon Anderson, Barry M. Brenner

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

The biologic price of aging includes progressive deterioration of renal function and structure. After the age of 30, glomerular filtration and renal blood flow rates decline in a linear fashion, so that values in octagenarians are only half to two thirds those measured in young adults. Renal mass similarly declines, and the incidence of sclerotic glomeruli increases with advancing age. Accordingly, the aging kidney is at high risk of eventual failure when functioning nephron number is further reduced by acquired renal disease. Recent evidence suggests that limitation of dietary protein intake delays the development of age-and disease-related glomerular sclerosis in experimental animals, and that dietary protein restriction may postpone end-stage renal disease in patients with progressive renal insufficiency.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalThe American journal of medicine
Volume80
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

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Kidney
Dietary Proteins
Renal Circulation
Nephrons
Sclerosis
Chronic Kidney Failure
Renal Insufficiency
Young Adult
Incidence

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Effects of aging on the renal glomerulus. / Anderson, Sharon; Brenner, Barry M.

In: The American journal of medicine, Vol. 80, No. 3, 1986, p. 435-442.

Research output: Contribution to journalArticle

Anderson, Sharon ; Brenner, Barry M. / Effects of aging on the renal glomerulus. In: The American journal of medicine. 1986 ; Vol. 80, No. 3. pp. 435-442.
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