TY - JOUR
T1 - Effects of aging on the renal glomerulus
AU - Anderson, Sharon
AU - Brenner, Barry M.
N1 - Funding Information:
From the Laboratory of Kidney and Electrolyte Physiology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts. Studies in the authors’ laboratory were supported by United States Public Health Service Grants AM 19467 and AM 30410. Dr. Anderson is the recipient of an Individual National Service Award of the National Institutes of Health (S F32 AM 07206). Requests for reprints should be addressed to Dr. Barry M. Brenner, Renal Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115. Manuscript accepted May 2, 1985.
PY - 1986/3
Y1 - 1986/3
N2 - The biologic price of aging includes progressive deterioration of renal function and structure. After the age of 30, glomerular filtration and renal blood flow rates decline in a linear fashion, so that values in octagenarians are only half to two thirds those measured in young adults. Renal mass similarly declines, and the incidence of sclerotic glomeruli increases with advancing age. Accordingly, the aging kidney is at high risk of eventual failure when functioning nephron number is further reduced by acquired renal disease. Recent evidence suggests that limitation of dietary protein intake delays the development of age-and disease-related glomerular sclerosis in experimental animals, and that dietary protein restriction may postpone end-stage renal disease in patients with progressive renal insufficiency.
AB - The biologic price of aging includes progressive deterioration of renal function and structure. After the age of 30, glomerular filtration and renal blood flow rates decline in a linear fashion, so that values in octagenarians are only half to two thirds those measured in young adults. Renal mass similarly declines, and the incidence of sclerotic glomeruli increases with advancing age. Accordingly, the aging kidney is at high risk of eventual failure when functioning nephron number is further reduced by acquired renal disease. Recent evidence suggests that limitation of dietary protein intake delays the development of age-and disease-related glomerular sclerosis in experimental animals, and that dietary protein restriction may postpone end-stage renal disease in patients with progressive renal insufficiency.
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U2 - 10.1016/0002-9343(86)90718-7
DO - 10.1016/0002-9343(86)90718-7
M3 - Review article
C2 - 3513560
AN - SCOPUS:0022608327
SN - 0002-9343
VL - 80
SP - 435
EP - 442
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 3
ER -