Effects of acute thyroxin depletion on hearing in humans

Zan Mra, Mark Wax

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To study the physiologic effect of acute thyroid hormone depletion on hearing and the function of outer hair cells. Design: Audiologic and otoacoustic emission testing of subjects undergoing total thyroidectomy before surgery and up to 6 weeks after surgery. Magnitude of thyroxin depletion monitored by serum thyroid-stimulating hormone levels. Setting: Hearing research laboratory at a state university. Subjects: Ten patients undergoing total thyroidectomy. Main Outcome Measures: Detection of hearing loss on audiogram and decrease or disappearance of otoacoustic emissions as a result of acute thyroxin depletion. Results: No significant changes in the audiogram and otoacoustic emission configurations were detected, although thyroid-stimulating hormone levels became elevated after total thyroidectomy. Conclusion: Although thyroid hormone is thought to play a role in the physiology of hearing in humans, no deleterious effects on hearing can be identified up to 6 weeks after thyroxin depletion.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalLaryngoscope
Volume109
Issue number3
StatePublished - 1999

Fingerprint

Thyroxine
Hearing
Thyroidectomy
Thyrotropin
Thyroid Hormones
Outer Auditory Hair Cells
Hearing Loss
Outcome Assessment (Health Care)
Serum
Research

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effects of acute thyroxin depletion on hearing in humans. / Mra, Zan; Wax, Mark.

In: Laryngoscope, Vol. 109, No. 3, 1999, p. 343-350.

Research output: Contribution to journalArticle

Mra, Zan ; Wax, Mark. / Effects of acute thyroxin depletion on hearing in humans. In: Laryngoscope. 1999 ; Vol. 109, No. 3. pp. 343-350.
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