Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice

Tamara Phillips, M. Huson, C. Gwiazdon, S. Burkhart-Kasch, E. H. Shen

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead to a more in-depth understanding of the constituents of alcohol addiction. Locomotor activity responses to acute and repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice and their C57BL/6J (B6) and DBA/2J (D2) progenitors. Both the acute response and the change in initial EtOH response with repeated treatments were strain-dependent. The coefficient of genetic determination was 0.38-0.49 for initial locomotor response to EtOH, and 0.29 for change in response. Changes in response were largely attributable to sensitization of locomotor stimulation. Quantitative trait loci (QTL) analyses identified significant marker associations with basal activity, acute locomotor response, and change in response. Markers were for QTL on several chromosomes, and there was only one case of overlap in marker associations among phenotypes. Acute locomotor response and locomotor sensitization were negatively correlated with 3% EtOH preference drinking data collected in BXD RI strains. Overall, these results demonstrate locomotor sensitization induced by EtOH, suggest independence of genetic determination of locomotor responses to acute and repeated EtOH exposure, and partially support a relationship between reduced sensitivity to the locomotor stimulant/sensitizing effects of EtOH and EtOH consumption.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume19
Issue number2
StatePublished - 1995

Fingerprint

Quantitative Trait Loci
Locomotion
Ethanol
Chromosomes
Inbred C57BL Mouse
Alcoholism
Drinking
Alcohols
Phenotype

Keywords

  • Activity
  • BXD Recombinant Inbreds
  • Ethanol
  • Quantitative Trait Loci
  • Sensitization

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. / Phillips, Tamara; Huson, M.; Gwiazdon, C.; Burkhart-Kasch, S.; Shen, E. H.

In: Alcoholism: Clinical and Experimental Research, Vol. 19, No. 2, 1995, p. 269-278.

Research output: Contribution to journalArticle

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