Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat: studies with enflurane, pentylenetetrazol, penicillin, and chloralose

R. R. Myers, Kim Burchiel, J. J. Stockard, R. G. Bickford

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Effects of acute and chronic paleocerebellar stimulation were evaluated in four experimental models of epilepsy in 24 adult cats chronically implanted with bilaterally symmetric parasagittal electrocorticographic electrodes and anterior lobe cerebellar stimulation electrodes. Pentylenetetrazol was given intravenously in 50 mg increments or 4% enflurane was inspired until grand mal seizures occurred spontaneously or were triggered by photic or auditory stimuli. Alpha chloralose, 50 mg/kg, was injected intraperitoneally to produce a model of stimulus sensitive myoclonus and sodium penicillin G, 350,000 units/kg, was injected intramuscularly to produce a model of petit mal epilepsy. One to 250 Hz electrical stimulation of paleocerebellar cortical surfaces was performed with constant voltage or constant current stimulators at threshold and suprathreshold intensities with average intensities of 8 V and 2.5 mA, respectively. Acute or chronic, threshold or suprathreshold paleocerebellar stimulation did not predictably alter the electrographic or clinical manifestations in any of these four models.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalEpilepsia
Volume16
Issue number2
StatePublished - 1975
Externally publishedYes

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Enflurane
Chloralose
Pentylenetetrazole
Penicillins
Epilepsy
Electrodes
Cats
Theoretical Models
Absence Epilepsy
Myoclonus
Penicillin G
Electric Stimulation
Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat : studies with enflurane, pentylenetetrazol, penicillin, and chloralose. / Myers, R. R.; Burchiel, Kim; Stockard, J. J.; Bickford, R. G.

In: Epilepsia, Vol. 16, No. 2, 1975, p. 257-267.

Research output: Contribution to journalArticle

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