Effects of acute alcohol administration on object recognition learning in C57BL/6J mice.

Andrey E. Ryabinin, Mark N. Miller, Shane Durrant

Research output: Contribution to journalArticle

Abstract

The goal of the present study was to investigate effects of alcohol intoxication on the object recognition learning task. Male C57BL/6J mice habituated to saline injections and exploratory arena received different doses of ethanol (0, 1.6 or 2.4 g/kg) before or after a 10-min training session. During training, animals were exposed to a small object (a marble or a die). On the next day, during a 10-min testing session, animals were exposed to two objects: the familiar object from the previous day and a novel object. Analysis of behavior during testing showed that mice injected with 0 and 1.6 g/kg of ethanol before training spent more time exploring a novel than a familiar object during testing. In contrast, mice injected with 2.4 g/kg ethanol spent equal amounts of time exploring the novel and the familiar object. Mice injected with this dose of ethanol after training did not show a decreased ratio of object exploration during testing. Analysis of behavior during training showed that mice injected with this dose of ethanol spent less time exploring the object, although their locomotor activity was not decreased. Our results show that in C57BL/6J mice, ethanol intoxication interferes with exploratory activity during object exploration, but not with consolidation of memory.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume71
Issue number1-2
StatePublished - Jan 2002

Fingerprint

Object recognition
Inbred C57BL Mouse
Ethanol
Alcohols
Learning
Testing
Animals
Alcoholic Intoxication
Calcium Carbonate
Locomotion
Consolidation
Recognition (Psychology)
Data storage equipment
Injections

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of acute alcohol administration on object recognition learning in C57BL/6J mice. / Ryabinin, Andrey E.; Miller, Mark N.; Durrant, Shane.

In: Pharmacology Biochemistry and Behavior, Vol. 71, No. 1-2, 01.2002, p. 307-312.

Research output: Contribution to journalArticle

@article{475c45c35ff64069a95a8e45209f646f,
title = "Effects of acute alcohol administration on object recognition learning in C57BL/6J mice.",
abstract = "The goal of the present study was to investigate effects of alcohol intoxication on the object recognition learning task. Male C57BL/6J mice habituated to saline injections and exploratory arena received different doses of ethanol (0, 1.6 or 2.4 g/kg) before or after a 10-min training session. During training, animals were exposed to a small object (a marble or a die). On the next day, during a 10-min testing session, animals were exposed to two objects: the familiar object from the previous day and a novel object. Analysis of behavior during testing showed that mice injected with 0 and 1.6 g/kg of ethanol before training spent more time exploring a novel than a familiar object during testing. In contrast, mice injected with 2.4 g/kg ethanol spent equal amounts of time exploring the novel and the familiar object. Mice injected with this dose of ethanol after training did not show a decreased ratio of object exploration during testing. Analysis of behavior during training showed that mice injected with this dose of ethanol spent less time exploring the object, although their locomotor activity was not decreased. Our results show that in C57BL/6J mice, ethanol intoxication interferes with exploratory activity during object exploration, but not with consolidation of memory.",
author = "Ryabinin, {Andrey E.} and Miller, {Mark N.} and Shane Durrant",
year = "2002",
month = "1",
language = "English (US)",
volume = "71",
pages = "307--312",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Effects of acute alcohol administration on object recognition learning in C57BL/6J mice.

AU - Ryabinin, Andrey E.

AU - Miller, Mark N.

AU - Durrant, Shane

PY - 2002/1

Y1 - 2002/1

N2 - The goal of the present study was to investigate effects of alcohol intoxication on the object recognition learning task. Male C57BL/6J mice habituated to saline injections and exploratory arena received different doses of ethanol (0, 1.6 or 2.4 g/kg) before or after a 10-min training session. During training, animals were exposed to a small object (a marble or a die). On the next day, during a 10-min testing session, animals were exposed to two objects: the familiar object from the previous day and a novel object. Analysis of behavior during testing showed that mice injected with 0 and 1.6 g/kg of ethanol before training spent more time exploring a novel than a familiar object during testing. In contrast, mice injected with 2.4 g/kg ethanol spent equal amounts of time exploring the novel and the familiar object. Mice injected with this dose of ethanol after training did not show a decreased ratio of object exploration during testing. Analysis of behavior during training showed that mice injected with this dose of ethanol spent less time exploring the object, although their locomotor activity was not decreased. Our results show that in C57BL/6J mice, ethanol intoxication interferes with exploratory activity during object exploration, but not with consolidation of memory.

AB - The goal of the present study was to investigate effects of alcohol intoxication on the object recognition learning task. Male C57BL/6J mice habituated to saline injections and exploratory arena received different doses of ethanol (0, 1.6 or 2.4 g/kg) before or after a 10-min training session. During training, animals were exposed to a small object (a marble or a die). On the next day, during a 10-min testing session, animals were exposed to two objects: the familiar object from the previous day and a novel object. Analysis of behavior during testing showed that mice injected with 0 and 1.6 g/kg of ethanol before training spent more time exploring a novel than a familiar object during testing. In contrast, mice injected with 2.4 g/kg ethanol spent equal amounts of time exploring the novel and the familiar object. Mice injected with this dose of ethanol after training did not show a decreased ratio of object exploration during testing. Analysis of behavior during training showed that mice injected with this dose of ethanol spent less time exploring the object, although their locomotor activity was not decreased. Our results show that in C57BL/6J mice, ethanol intoxication interferes with exploratory activity during object exploration, but not with consolidation of memory.

UR - http://www.scopus.com/inward/record.url?scp=0036357791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036357791&partnerID=8YFLogxK

M3 - Article

C2 - 11812537

VL - 71

SP - 307

EP - 312

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 1-2

ER -