Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes

Radko Komers, Renata Simkova, Ludmila Kazdova, Jana Ruzickova, Terezie Pelikanova

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction. Angiotensin-converting enzyme (ACE) inhibitors have been shown to improve endothelial function in Type 1 diabetes. However, the potential of ACE inhibitors (ACE-I) to enhance the haemodynamic effects of L-arginine (L-arg), the precursor of nitric oxide (NO), has not been evaluated. Furthermore, angiotensin receptor blockers (ARBs), another group of inhibitors of the renin-angiotensin system (RAS), have not been studied in this context. Methods. Using a randomised, crossover design, the acute effects of L-arg (200 mg/kg) on blood pressure (BP) and renal haemodynamics were determined in uncomplicated Type 1 diabetic patients before and after three weeks of treatment with the ACE-I ramipril (5 mg/day) or the ARB losartan (50 mg/day). Results. L-arg alone did not influence BP or renal haemodynamics. BP responses to L-arg were not modulated by ACE-I or ARB. In contrast to the systemic responses, L-arg induced significant renal vasodilation after treatment with ramipril (p

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume5
Issue number1
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Angiotensin Receptor Antagonists
Peptidyl-Dipeptidase A
Type 1 Diabetes Mellitus
Ramipril
Arginine
Hemodynamics
Blood Pressure
Kidney
Angiotensin-Converting Enzyme Inhibitors
Losartan
Renin-Angiotensin System
Vasodilation
Cross-Over Studies
Nitric Oxide
Therapeutics

Keywords

  • Angiotensin receptor blockers
  • Angiotensin-converting enzyme inhibitors
  • Blood pressure
  • Diabetes
  • L-arginine
  • Renal haemodynamics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes. / Komers, Radko; Simkova, Renata; Kazdova, Ludmila; Ruzickova, Jana; Pelikanova, Terezie.

In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol. 5, No. 1, 03.2004, p. 33-38.

Research output: Contribution to journalArticle

Komers, Radko ; Simkova, Renata ; Kazdova, Ludmila ; Ruzickova, Jana ; Pelikanova, Terezie. / Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes. In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System. 2004 ; Vol. 5, No. 1. pp. 33-38.
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