Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

Jon M. Hanifin, Adelaide A. Hebert, Steven R. Mays, Amy S. Paller, Elizabeth F. Sherertz, Annette M. Wagner, Michael R. Tuley, Michael D. Baker

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume59
Issue number4
DOIs
StatePublished - Jan 1 1998

Keywords

  • Atopic dermatitis
  • Corticosteroid lotion
  • Low- potency steroid therapy
  • Moisturizing regimen

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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