Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

Jon Hanifin, Adelaide A. Hebert, Steven R. Mays, Amy S. Paller, Elizabeth F. Sherertz, Annette M. Wagner, Michael R. Tuley, Michael D. Baker

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume59
Issue number4
DOIs
StatePublished - 1998

Fingerprint

Desonide
Atopic Dermatitis
Signs and Symptoms
Adrenal Cortex Hormones
Pruritus
Erythema
Therapeutics
Research Personnel
Inflammation
Physicians
Skin
Infection

Keywords

  • Atopic dermatitis
  • Corticosteroid lotion
  • Low- potency steroid therapy
  • Moisturizing regimen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis. / Hanifin, Jon; Hebert, Adelaide A.; Mays, Steven R.; Paller, Amy S.; Sherertz, Elizabeth F.; Wagner, Annette M.; Tuley, Michael R.; Baker, Michael D.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 59, No. 4, 1998, p. 227-233.

Research output: Contribution to journalArticle

Hanifin, Jon ; Hebert, Adelaide A. ; Mays, Steven R. ; Paller, Amy S. ; Sherertz, Elizabeth F. ; Wagner, Annette M. ; Tuley, Michael R. ; Baker, Michael D. / Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis. In: Current Therapeutic Research - Clinical and Experimental. 1998 ; Vol. 59, No. 4. pp. 227-233.
@article{9377f85e57a84530a430ef985ed65a42,
title = "Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis",
abstract = "Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05{\%} alone with twice- daily applications of desonide lotion 0.05{\%} plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.",
keywords = "Atopic dermatitis, Corticosteroid lotion, Low- potency steroid therapy, Moisturizing regimen",
author = "Jon Hanifin and Hebert, {Adelaide A.} and Mays, {Steven R.} and Paller, {Amy S.} and Sherertz, {Elizabeth F.} and Wagner, {Annette M.} and Tuley, {Michael R.} and Baker, {Michael D.}",
year = "1998",
doi = "10.1016/S0011-393X(98)85076-5",
language = "English (US)",
volume = "59",
pages = "227--233",
journal = "Current Therapeutic Research",
issn = "0011-393X",
publisher = "Excerpta Medica",
number = "4",

}

TY - JOUR

T1 - Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

AU - Hanifin, Jon

AU - Hebert, Adelaide A.

AU - Mays, Steven R.

AU - Paller, Amy S.

AU - Sherertz, Elizabeth F.

AU - Wagner, Annette M.

AU - Tuley, Michael R.

AU - Baker, Michael D.

PY - 1998

Y1 - 1998

N2 - Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.

AB - Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.

KW - Atopic dermatitis

KW - Corticosteroid lotion

KW - Low- potency steroid therapy

KW - Moisturizing regimen

UR - http://www.scopus.com/inward/record.url?scp=0031955805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031955805&partnerID=8YFLogxK

U2 - 10.1016/S0011-393X(98)85076-5

DO - 10.1016/S0011-393X(98)85076-5

M3 - Article

AN - SCOPUS:0031955805

VL - 59

SP - 227

EP - 233

JO - Current Therapeutic Research

JF - Current Therapeutic Research

SN - 0011-393X

IS - 4

ER -