Effects of 56Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli

Jacob Raber, Susanna Rosi, Ayanabha Chakraborti, Kelly Fishman, Catherine Dayger, Matthew J. Davis, Laura Villasana, John R. Fike

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ionizing radiation reduces the numbers of neurons expressing activity-regulated cytoskeleton-associated protein (Arc) in the hippocampal dentate gyrus (DG). It is currently unclear if that change relates to cognitive function. We assessed the effects of 1 Gy of head-only 56Fe-particle irradiation on hippocampus-dependent and hippocampus-independent fear conditioning and determined how those changes related to Arc expression within the DG. Irradiated mice that did not receive tone-shock pairings on day 1 showed less freezing in the same context on a second day and a lower fraction of Arc-expressing neurons in the free (lower) blade of the DG than sham-irradiated mice. Those data suggested reduced hippocampus-dependent spatial habituation learning. Changes in Arc expression in the free blade correlated positively with freezing in mice that did not receive tone-shock pairings. However, irradiated mice that did receive tone-shock pairings showed enhanced contextual freezing but a reduced percentage of Arc-expressing neurons in the enclosed (upper) blade. Changes in Arc expression correlated negatively with freezing in mice that received tone-shock pairings. In animals receiving cued fear conditioning, radiation did not affect cognitive performance or the fractions of Arc-expressing neurons. While the relationship between Arc expression and cognitive performance is complex, our data suggest that radiation effects on hippocampus-dependent cognition might depend on the prominence (salience) of environmental stimuli and blade-specific Arc expression.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalRadiation Research
Volume176
Issue number4
DOIs
StatePublished - Oct 2011

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hippocampus
cognition
Cytoskeleton
stimuli
Cognition
Hippocampus
Radiation
proteins
radiation
mice
blades
neurons
freezing
Freezing
Proteins
Shock
Dentate Gyrus
shock
fear
Neurons

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Effects of 56Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. / Raber, Jacob; Rosi, Susanna; Chakraborti, Ayanabha; Fishman, Kelly; Dayger, Catherine; Davis, Matthew J.; Villasana, Laura; Fike, John R.

In: Radiation Research, Vol. 176, No. 4, 10.2011, p. 521-526.

Research output: Contribution to journalArticle

Raber, Jacob ; Rosi, Susanna ; Chakraborti, Ayanabha ; Fishman, Kelly ; Dayger, Catherine ; Davis, Matthew J. ; Villasana, Laura ; Fike, John R. / Effects of 56Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. In: Radiation Research. 2011 ; Vol. 176, No. 4. pp. 521-526.
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