Effectiveness of posterolateral lumbar fusion varies with the physical properties of demineralized bone matrix strip

Yong Soo Choi, Dae Hee Kim, Ji Hun Park, Brian Johnstone, Jung Yoo

Research output: Contribution to journalArticle

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Abstract

Study Design: A randomized, controlled animal study. Purpose: To investigate the effectiveness of fusion and new bone formation induced by demineralized bone matrix (DBM) strips with jelly strengths. Overview of Literature: The form of the DBM can make a difference to the outcome. The effect of different jelly strengths on the ability of DBM to form new bone is not known. Methods: Forty-eight rabbits were randomized into a control group and two experimental groups. In the control group (group 1), 1.4 g of autologous iliac crest bone was placed bilaterally. In the experimental groups, a high jelly strength DBM-hyaluronic acid (HA)-gelatin strip (group 2) and a low jelly strength DBM-HA-gelatin strip (group 3) were used. The fusion was assessed with manual manipulation and radiographs. The volume of the fusion mass was determined from computed tomographic images. Results: The fusion rates as determined by manual palpation were 37.5%, 93.8% and 50.0% in group 1, group 2, and group 3, respectively (p 3, 3,132.9±632.1 mm3, and 2,741.5±380.4 mm3 in group 1, group 2, and group 3, respectively (p

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalAsian Spine Journal
Volume9
Issue number3
DOIs
Publication statusPublished - 2015

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Keywords

  • Demineralized bone matrix
  • Spinal fusion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

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