Effectiveness and safety of fentanyl compared with morphine for out-of-hospital analgesia

Ross J. Fleischman, David G. Frazer, Mohamud Ramzan Daya, Jonathan Jui, Craig Newgard

Research output: Contribution to journalArticle

25 Scopus citations


Background. Fentanyl has several potential advantages for out-of-hospital analgesia, including rapid onset, short duration, and less histamine release. Objective. To compare the effectiveness and safety of fentanyl with that of morphine. Methods. This was a retrospective before-and-after study of a protocol change from morphine to fentanyl in an advanced life support emergency medical services system in January 2007. Charts from nine months prior to the change and for nine months afterward were abstracted by two reviewers using a standardized instrument. The first three months after the change were excluded. Effectiveness was measured by change in pain scores on a 010 scale. A prioridefined adverse events included out-of-hospital events: respiratory rate

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalPrehospital Emergency Care
Issue number2
Publication statusPublished - 2010



  • Analgesia
  • Analgesics, opioid
  • Emergency medical services
  • Fentanyl
  • Morphine
  • Prehospital emergency care

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Medicine(all)

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