Effect of truncal vagotomy on bile kinetics in rhesus monkeys

Clifford Deveney, B. N. Gardiner, L. W. Way

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using female rhesus monkeys that had undergone cholecystectomy and had intact enterohepatic circulation, the effect of vagotomy on the composition and daily secretion of bile was investigated. In addition, the size of the bile salt pool and rate of enterohepatic circulation were determined before and after vagotomy. Since the rate of bile salt secretion is dependent upon the pool size and the number of daily enterohepatic circulations, it appears that the prolonged enterohepatic circulation time is the cause of decreased bile salt secretion following vagotomy. The parallel reduction in phospholipid secretion with diminished bile salt output conforms to the general observation that the secretory rates of these two substances are closely coupled. Daily cholesterol secretion was relatively constant, and independent of bile salt and phospholipid secretion. A similar pattern of results has been reported to follow vagotomy in dogs that have had cholecystectomy. The findings suggest a possible mechanism for the as yet unproved relationship of gallstone disease to vagotomy in man.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
JournalSurgical Forum
VolumeVol 25
StatePublished - 1974
Externally publishedYes

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Truncal Vagotomy
Vagotomy
Enterohepatic Circulation
Macaca mulatta
Bile Acids and Salts
Bile
Cholecystectomy
Phospholipids
Secretory Rate
Gallstones
Cholesterol
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Deveney, C., Gardiner, B. N., & Way, L. W. (1974). Effect of truncal vagotomy on bile kinetics in rhesus monkeys. Surgical Forum, Vol 25, 402-404.

Effect of truncal vagotomy on bile kinetics in rhesus monkeys. / Deveney, Clifford; Gardiner, B. N.; Way, L. W.

In: Surgical Forum, Vol. Vol 25, 1974, p. 402-404.

Research output: Contribution to journalArticle

Deveney, C, Gardiner, BN & Way, LW 1974, 'Effect of truncal vagotomy on bile kinetics in rhesus monkeys', Surgical Forum, vol. Vol 25, pp. 402-404.
Deveney, Clifford ; Gardiner, B. N. ; Way, L. W. / Effect of truncal vagotomy on bile kinetics in rhesus monkeys. In: Surgical Forum. 1974 ; Vol. Vol 25. pp. 402-404.
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