Using female rhesus monkeys that had undergone cholecystectomy and had intact enterohepatic circulation, the effect of vagotomy on the composition and daily secretion of bile was investigated. In addition, the size of the bile salt pool and rate of enterohepatic circulation were determined before and after vagotomy. Since the rate of bile salt secretion is dependent upon the pool size and the number of daily enterohepatic circulations, it appears that the prolonged enterohepatic circulation time is the cause of decreased bile salt secretion following vagotomy. The parallel reduction in phospholipid secretion with diminished bile salt output conforms to the general observation that the secretory rates of these two substances are closely coupled. Daily cholesterol secretion was relatively constant, and independent of bile salt and phospholipid secretion. A similar pattern of results has been reported to follow vagotomy in dogs that have had cholecystectomy. The findings suggest a possible mechanism for the as yet unproved relationship of gallstone disease to vagotomy in man.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 1 1974|
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