Effect of triethyllead on protein synthesis in rat forebrain

G. Konat; H. Offner; J. Clausen

doi:10.1016/0014-4886(78)90209-1

Effect of triethyllead on protein synthesis in rat forebrain

G. Konat, H. Offner, J. Clausen

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Triethyllead (PbEt₃) inhibited both oxygen utilization and l-[U-¹⁴C]-leucine incorporation into acid-insoluble protein in a cell suspension prepared from 20-day-old rat forebrain. At the same concentrations of PbEt₃, protein synthesis was inhibited more than respiration. The cell-free protein synthesis studied in the cytopalsmic fraction was not affected by the neurotoxin. Thus, PbEt₃ does not directly interfere with the protein synthesizing systems and the observed inhibition is secondary to the suppression of the tissue oxidative metabolism.

Original language	English (US)
Pages (from-to)	162-167
Number of pages	6
Journal	Experimental Neurology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(78)90209-1
State	Published - Mar 1978
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1016/0014-4886(78)90209-1

Cite this

@article{9730477d59134a27b63a8a52e969e118,

title = "Effect of triethyllead on protein synthesis in rat forebrain",

abstract = "Triethyllead (PbEt3) inhibited both oxygen utilization and l-[U-14C]-leucine incorporation into acid-insoluble protein in a cell suspension prepared from 20-day-old rat forebrain. At the same concentrations of PbEt3, protein synthesis was inhibited more than respiration. The cell-free protein synthesis studied in the cytopalsmic fraction was not affected by the neurotoxin. Thus, PbEt3 does not directly interfere with the protein synthesizing systems and the observed inhibition is secondary to the suppression of the tissue oxidative metabolism.",

author = "G. Konat and H. Offner and J. Clausen",

year = "1978",

month = mar,

doi = "10.1016/0014-4886(78)90209-1",

language = "English (US)",

volume = "59",

pages = "162--167",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Effect of triethyllead on protein synthesis in rat forebrain

AU - Konat, G.

AU - Offner, H.

AU - Clausen, J.

PY - 1978/3

Y1 - 1978/3

N2 - Triethyllead (PbEt3) inhibited both oxygen utilization and l-[U-14C]-leucine incorporation into acid-insoluble protein in a cell suspension prepared from 20-day-old rat forebrain. At the same concentrations of PbEt3, protein synthesis was inhibited more than respiration. The cell-free protein synthesis studied in the cytopalsmic fraction was not affected by the neurotoxin. Thus, PbEt3 does not directly interfere with the protein synthesizing systems and the observed inhibition is secondary to the suppression of the tissue oxidative metabolism.

AB - Triethyllead (PbEt3) inhibited both oxygen utilization and l-[U-14C]-leucine incorporation into acid-insoluble protein in a cell suspension prepared from 20-day-old rat forebrain. At the same concentrations of PbEt3, protein synthesis was inhibited more than respiration. The cell-free protein synthesis studied in the cytopalsmic fraction was not affected by the neurotoxin. Thus, PbEt3 does not directly interfere with the protein synthesizing systems and the observed inhibition is secondary to the suppression of the tissue oxidative metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0017817645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017817645&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(78)90209-1

DO - 10.1016/0014-4886(78)90209-1

M3 - Article

C2 - 627264

AN - SCOPUS:0017817645

SN - 0014-4886

VL - 59

SP - 162

EP - 167

JO - Experimental Neurology

JF - Experimental Neurology

IS - 1

ER -

Effect of triethyllead on protein synthesis in rat forebrain

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this