Effect of triethyllead on protein synthesis in rat forebrain

G. Konat, H. Offner, J. Clausen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Triethyllead (PbEt3) inhibited both oxygen utilization and l-[U-14C]-leucine incorporation into acid-insoluble protein in a cell suspension prepared from 20-day-old rat forebrain. At the same concentrations of PbEt3, protein synthesis was inhibited more than respiration. The cell-free protein synthesis studied in the cytopalsmic fraction was not affected by the neurotoxin. Thus, PbEt3 does not directly interfere with the protein synthesizing systems and the observed inhibition is secondary to the suppression of the tissue oxidative metabolism.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalExperimental Neurology
Volume59
Issue number1
DOIs
StatePublished - Mar 1978

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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