Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia

Lee Ratner; Christian Grant; Bevin Zimmerman; Joseph Fritz; Gary Weil; Alex Denes; Rama Suresh; Nancy Campbell; Steve Jacobson; Michael Lairmore

doi:10.1002/ajh.20929

Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia

Lee Ratner, Christian Grant, Bevin Zimmerman, Joseph Fritz, Gary Weil, Alex Denes, Rama Suresh, Nancy Campbell, Steve Jacobson, Michael Lairmore

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.

Original language	English (US)
Pages (from-to)	929-931
Number of pages	3
Journal	American Journal of Hematology
Volume	82
Issue number	10
DOIs	https://doi.org/10.1002/ajh.20929
State	Published - Oct 2007
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1002/ajh.20929

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title = "Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia",

abstract = "Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.",

author = "Lee Ratner and Christian Grant and Bevin Zimmerman and Joseph Fritz and Gary Weil and Alex Denes and Rama Suresh and Nancy Campbell and Steve Jacobson and Michael Lairmore",

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AU - Ratner, Lee

AU - Grant, Christian

AU - Zimmerman, Bevin

AU - Fritz, Joseph

AU - Weil, Gary

AU - Denes, Alex

AU - Suresh, Rama

AU - Campbell, Nancy

AU - Jacobson, Steve

AU - Lairmore, Michael

PY - 2007/10

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N2 - Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.

AB - Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.

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Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia

Abstract

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