Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats

Sergio Ojeda, P. G. Harms, S. M. McCann

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Prostaglandin E2 (PGE2) (5 μg in 5 μl) injected into the third ventricle (3rd V) of intact or castrated conscious male rats markedly increased plasma LH titers 15 and 30 min after its injection. PGE1 injected at a similar dose slightly increased plasma LH in intact but not in orchidectomized rats. A small but significant increase in plasma FSH followed 3rd V injection of both PGE2 and PGE1 in intact but not in castrated rats. PGF and PGF were completely ineffective in modifying plasma LH or FSH titers in either intact or castrated rats. These results indicate that PGE2 and to a lesser extent PGE1 specifically stimulate gonadotropin release in the male rat, possibly by a direct action on the central nervous system. They also support the hypothesis that PGE2 and perhaps PGE1 play a physiological role in neural control of pituitary gonadotropin release.

Original languageEnglish (US)
Pages (from-to)545-552
Number of pages8
JournalProstaglandins
Volume8
Issue number6
DOIs
StatePublished - Dec 25 1974
Externally publishedYes

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Gonadotropins
Alprostadil
Prostaglandins
Rats
Dinoprostone
Injections
Plasmas
Pituitary Gonadotropins
Third Ventricle
Dinoprost
Neurology
Central Nervous System

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats. / Ojeda, Sergio; Harms, P. G.; McCann, S. M.

In: Prostaglandins, Vol. 8, No. 6, 25.12.1974, p. 545-552.

Research output: Contribution to journalArticle

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