Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood

Daniel M. Gibbs, Wylie Vale

Research output: Contribution to journalArticle

166 Scopus citations


The relative role of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in mediating serotonin-induced ACTH secretion was studied using the serotonin reuptake inhibitor fluoxetine. Fluoxetine caused a significant increase in ACTH and AVP concentrations in peripheral plasma as well as a significant increase in CRF and AVP concentrations in hypophysial portal plasma. The data suggest that increased secretion of ACTH induced by fluoxetine is mediated, at least in part, by an increase in the hypothalamic secretion of both CRF and AVP.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalBrain research
Issue number1
StatePublished - Nov 28 1983



  • ACTH
  • CRF
  • fluoxetine
  • hypophysial portal blood
  • serotonin
  • vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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