@article{ab84b00e08e740c4aa9fb6dfa94cb304,
title = "Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood",
abstract = "The relative role of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in mediating serotonin-induced ACTH secretion was studied using the serotonin reuptake inhibitor fluoxetine. Fluoxetine caused a significant increase in ACTH and AVP concentrations in peripheral plasma as well as a significant increase in CRF and AVP concentrations in hypophysial portal plasma. The data suggest that increased secretion of ACTH induced by fluoxetine is mediated, at least in part, by an increase in the hypothalamic secretion of both CRF and AVP.",
keywords = "ACTH, CRF, fluoxetine, hypophysial portal blood, serotonin, vasopressin",
author = "Gibbs, {Daniel M.} and Wylie Vale",
note = "Funding Information: This study was supportedin part by a grant trom the Mellon Foundationa ndby Nl H Grant HD 13527 We would like to thank Dr. J. Clemenso f Litlv Re-searchL aboratoriefso r the gift of fluoxetinea nd C Douglas and R. Stewart for technical assistance. D.M.G. would like to acknowledgteh e supporta nd encouragemeonft Dr. S. C. C. Yen 4 Fuller.R . W andW ong,D . T.. Inhibitiono f serotoniunp - takeF. ed. Proc.. 36( 19772) 154-2158. 5 GalliardR. . C., GrossmanA,. . Gillies,G .. Rees,L . H. and Besser. G, M., AngiotensinII stimulatetsh e releaseo f ACTH fromd isperserda ta nteriopri tuitarcye lls,C lin. En-docrinol.. 15( 19815) 73-578. 6 Gibbs.D . M.. Collectiono f pituitarpy ortabl lood:a meth-odologiac nalysisN. euroendocrinology, in press.",
year = "1983",
month = nov,
day = "28",
doi = "10.1016/0006-8993(83)91189-7",
language = "English (US)",
volume = "280",
pages = "176--179",
journal = "Brain research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}