Effect of the radioprotector WR2721 on irradiation-induced injury to ciliated cells of eustachian tube

T. T K Jung, Y. M. Park, D. Panossian, Douglas Weeks, S. K. Miller, J. Sandefur, Kenneth Krohn

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Our previous studies revealed that injury to the ciliated cells of the eustachian tube may be the primary cause of irradiation-induced serous otitis media. The purpose of this study was to investigate the effects of the radioprotector WR2721 on irradiation-induced injury to ciliated cells of the eustachian tube (ET) in chinchillas. Twelve chinchillas were divided into two groups: the control group and the experimental group, which was pretreated with a single intraperitoneal dose of the radioprotector S-2-[3- aminopropylamino]ethylphosphorothioic acid (WR2721) 400 mg/kg. The two groups were exposed to 30 Gy of 13-MeV electrons in a single fraction to the area of the bullae and nasopharynx. Ciliary dysfunction was tested and ciliated cells of the ET were examined by scanning and transmission electron microscopy. Pretreatment with WR2721 was found to protect ciliated cells of the ET from irradiation injury.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume101
Issue number5
Publication statusPublished - 1992
Externally publishedYes

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Keywords

  • ciliated cells of eustachian tube
  • eustachian tube function
  • radiation injury
  • radiation- induced otitis media
  • radioprotector WR2721

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Jung, T. T. K., Park, Y. M., Panossian, D., Weeks, D., Miller, S. K., Sandefur, J., & Krohn, K. (1992). Effect of the radioprotector WR2721 on irradiation-induced injury to ciliated cells of eustachian tube. Annals of Otology, Rhinology and Laryngology, 101(5), 395-402.