Effect of the prostacyclin analogue, iloprost, on infarct size after permanent focal cerebral ischemia

Aclan Dogan, Cüneyt Temiz, R. Kazim Türker, Nihat Egemen, Mustafa K. Başkaya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This investigation was undertaken to study the effect of iloprost, a stable analogue of prostacyclin, on infarct size after permanent focal cerebral ischemia in the rabbit. Forty-two adult rabbits were subjected to left middle cerebral artery occlusion via the transorbital route. Fourteen rabbits received an intravenous (IV) infusion of 30 μg/kg iloprost, 7 rabhits received an IV infusion of 10 μg/kg, and 9 rabbits received an IV infusion of 20 μg/kg iloprost. Twelve rabbits received an intravenous infusion of saline. Treatment with iloprost started immediately after middle cerebral artery occlusion and continued for 1 h. After killing the animals, brains were removed and five coronal slices were incubated in a 2,3,5-triphenyltetrazolium chloride solution to determine the infarct size. Treatment with 30 μg/kg iloprost significantly reduced the infarct size compared with treatment with saline (3.49 ± 2.79% vs. 9.03 ± 4.26%, P

Original languageEnglish (US)
Pages (from-to)1163-1166
Number of pages4
JournalGeneral Pharmacology
Volume27
Issue number7
DOIs
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Iloprost
Epoprostenol
Brain Ischemia
Intravenous Infusions
Rabbits
Middle Cerebral Artery Infarction
Therapeutics
Brain

Keywords

  • focal cerebral ischemia
  • iloprost
  • prostacyclin
  • triphenyltetrazolium chloride

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of the prostacyclin analogue, iloprost, on infarct size after permanent focal cerebral ischemia. / Dogan, Aclan; Temiz, Cüneyt; Kazim Türker, R.; Egemen, Nihat; Başkaya, Mustafa K.

In: General Pharmacology, Vol. 27, No. 7, 10.1996, p. 1163-1166.

Research output: Contribution to journalArticle

Dogan, Aclan ; Temiz, Cüneyt ; Kazim Türker, R. ; Egemen, Nihat ; Başkaya, Mustafa K. / Effect of the prostacyclin analogue, iloprost, on infarct size after permanent focal cerebral ischemia. In: General Pharmacology. 1996 ; Vol. 27, No. 7. pp. 1163-1166.
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