Effect of sodium salicylate on human and mouse granulopoiesis in vitro

J. D. Gabourel, M. A.S. Moore, G. C. Bagby, G. H. Davies

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    1 Scopus citations

    Abstract

    Sodium salicylate inhibited generation of granulocyte and macrophage colonies when added to soft agar cultures of mouse or human bone marrow cells (CFUc) containing colony‐stimulating factor (CSF). This effect was dose‐dependent with over 90% inhibition at 48 mg%. The salicylate effect was not decreased with increasing concentrations of CSF, but inhibition was reversed when salicylate‐treated CFUc were washed with drug‐free medium before plating. CSF production was not inhibited by salicylate.

    Original languageEnglish (US)
    Pages (from-to)59-64
    Number of pages6
    JournalArthritis & Rheumatism
    Volume20
    Issue number1
    DOIs
    StatePublished - Jan 1 1977

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    ASJC Scopus subject areas

    • Immunology and Allergy
    • Rheumatology
    • Immunology
    • Pharmacology (medical)

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