Effect of Sodium Intake on Gentamicin Nephrotoxicity in the Rat

William M. Bennett, Michael N. Hartnett, David Gilbert, Donald Houghton, George A. Porter

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Gentamicin nephrotoxicity was examined in rats on normal, high, and low sodium diets. Low sodium diet markedly potentiated nephrotoxic effects of the drug as evidenced by animal mortality, renal failure, pathological changes, and increased renal cortical concentration of the drug. High sodium intake reduced the cortical concentration of gentamicin but renal function and ultrastructure were similar to normally fed rats given in the same dose.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume151
Issue number4
DOIs
StatePublished - Apr 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Effect of Sodium Intake on Gentamicin Nephrotoxicity in the Rat'. Together they form a unique fingerprint.

Cite this