TY - JOUR
T1 - Effect of Sodium Intake on Gentamicin Nephrotoxicity in the Rat
AU - Bennett, William M.
AU - Hartnett, Michael N.
AU - Gilbert, David
AU - Houghton, Donald
AU - Porter, George A.
PY - 1976/4
Y1 - 1976/4
N2 - Gentamicin nephrotoxicity was examined in rats on normal, high, and low sodium diets. Low sodium diet markedly potentiated nephrotoxic effects of the drug as evidenced by animal mortality, renal failure, pathological changes, and increased renal cortical concentration of the drug. High sodium intake reduced the cortical concentration of gentamicin but renal function and ultrastructure were similar to normally fed rats given in the same dose.
AB - Gentamicin nephrotoxicity was examined in rats on normal, high, and low sodium diets. Low sodium diet markedly potentiated nephrotoxic effects of the drug as evidenced by animal mortality, renal failure, pathological changes, and increased renal cortical concentration of the drug. High sodium intake reduced the cortical concentration of gentamicin but renal function and ultrastructure were similar to normally fed rats given in the same dose.
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U2 - 10.3181/00379727-151-39296
DO - 10.3181/00379727-151-39296
M3 - Article
C2 - 1265059
AN - SCOPUS:0017067033
SN - 0037-9727
VL - 151
SP - 736
EP - 738
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 4
ER -