Effect of Ro 15-4513 on ethanol-induced conditioned place preference

Fred O. Risinger, Dorcas H. Malott, Anthony L. Riley, Christopher Cunningham

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The benzodiazepine receptor inverse agonist Ro 15-4513 reverses a number of ethanol's effects, including its reinforcing properties as measured through self-administration. The present study examined the effect of this putative ethanol antagonist in a place conditioning design that has been shown to be sensitive to ethanol's rewarding properties in mice. Using an unbiased differential conditioning procedure, DBA/2J mice received, on alternate days, pairings of a distinctive floor stimulus (CS+) with either ethanol (2 g/kg), Ro 15-4513 (3 mg/kg), or a combination of ethanol and Ro 15-4513. On alternate days, a different distinctive floor stimulus (CS-) was paired with vehicle. Under these conditions, ethanol produced a conditioned place preference that was unaffected by Ro 15-4513. Ro 15-4513 alone did not produce either a place preference or aversion. Ro 15-4513 did produce reductions in locomotor activity during conditioning, indicating it was behaviorally active. These results indicate that a dose of Ro 15-4513 that alters general activity does not affect ethanol reward.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Ethanol
Inbred DBA Mouse
Self Administration
GABA-A Receptors
Locomotion
Ro 15-4513
Reward
Conditioning (Psychology)

Keywords

  • Conditioned place preference
  • DBA/2J
  • Ethanol
  • Inbred mice
  • Locomotor activity
  • Reward
  • Ro 15-4513

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effect of Ro 15-4513 on ethanol-induced conditioned place preference. / Risinger, Fred O.; Malott, Dorcas H.; Riley, Anthony L.; Cunningham, Christopher.

In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 1, 1992, p. 97-102.

Research output: Contribution to journalArticle

Risinger, Fred O. ; Malott, Dorcas H. ; Riley, Anthony L. ; Cunningham, Christopher. / Effect of Ro 15-4513 on ethanol-induced conditioned place preference. In: Pharmacology, Biochemistry and Behavior. 1992 ; Vol. 43, No. 1. pp. 97-102.
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