Abstract
The benzodiazepine receptor inverse agonist Ro 15-4513 reverses a number of ethanol's effects, including its reinforcing properties as measured through self-administration. The present study examined the effect of this putative ethanol antagonist in a place conditioning design that has been shown to be sensitive to ethanol's rewarding properties in mice. Using an unbiased differential conditioning procedure, DBA/2J mice received, on alternate days, pairings of a distinctive floor stimulus (CS+) with either ethanol (2 g/kg), Ro 15-4513 (3 mg/kg), or a combination of ethanol and Ro 15-4513. On alternate days, a different distinctive floor stimulus (CS-) was paired with vehicle. Under these conditions, ethanol produced a conditioned place preference that was unaffected by Ro 15-4513. Ro 15-4513 alone did not produce either a place preference or aversion. Ro 15-4513 did produce reductions in locomotor activity during conditioning, indicating it was behaviorally active. These results indicate that a dose of Ro 15-4513 that alters general activity does not affect ethanol reward.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-102 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Conditioned place preference
- DBA/2J
- Ethanol
- Inbred mice
- Locomotor activity
- Reward
- Ro 15-4513
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Effect of Ro 15-4513 on ethanol-induced conditioned place preference. / Risinger, Fred O.; Malott, Dorcas H.; Riley, Anthony L.; Cunningham, Christopher.
In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 1, 1992, p. 97-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Ro 15-4513 on ethanol-induced conditioned place preference
AU - Risinger, Fred O.
AU - Malott, Dorcas H.
AU - Riley, Anthony L.
AU - Cunningham, Christopher
PY - 1992
Y1 - 1992
N2 - The benzodiazepine receptor inverse agonist Ro 15-4513 reverses a number of ethanol's effects, including its reinforcing properties as measured through self-administration. The present study examined the effect of this putative ethanol antagonist in a place conditioning design that has been shown to be sensitive to ethanol's rewarding properties in mice. Using an unbiased differential conditioning procedure, DBA/2J mice received, on alternate days, pairings of a distinctive floor stimulus (CS+) with either ethanol (2 g/kg), Ro 15-4513 (3 mg/kg), or a combination of ethanol and Ro 15-4513. On alternate days, a different distinctive floor stimulus (CS-) was paired with vehicle. Under these conditions, ethanol produced a conditioned place preference that was unaffected by Ro 15-4513. Ro 15-4513 alone did not produce either a place preference or aversion. Ro 15-4513 did produce reductions in locomotor activity during conditioning, indicating it was behaviorally active. These results indicate that a dose of Ro 15-4513 that alters general activity does not affect ethanol reward.
AB - The benzodiazepine receptor inverse agonist Ro 15-4513 reverses a number of ethanol's effects, including its reinforcing properties as measured through self-administration. The present study examined the effect of this putative ethanol antagonist in a place conditioning design that has been shown to be sensitive to ethanol's rewarding properties in mice. Using an unbiased differential conditioning procedure, DBA/2J mice received, on alternate days, pairings of a distinctive floor stimulus (CS+) with either ethanol (2 g/kg), Ro 15-4513 (3 mg/kg), or a combination of ethanol and Ro 15-4513. On alternate days, a different distinctive floor stimulus (CS-) was paired with vehicle. Under these conditions, ethanol produced a conditioned place preference that was unaffected by Ro 15-4513. Ro 15-4513 alone did not produce either a place preference or aversion. Ro 15-4513 did produce reductions in locomotor activity during conditioning, indicating it was behaviorally active. These results indicate that a dose of Ro 15-4513 that alters general activity does not affect ethanol reward.
KW - Conditioned place preference
KW - DBA/2J
KW - Ethanol
KW - Inbred mice
KW - Locomotor activity
KW - Reward
KW - Ro 15-4513
UR - http://www.scopus.com/inward/record.url?scp=0026671679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026671679&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(92)90644-U
DO - 10.1016/0091-3057(92)90644-U
M3 - Article
C2 - 1409822
AN - SCOPUS:0026671679
VL - 43
SP - 97
EP - 102
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 1
ER -