Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease

Richard J. Bloomer, Brian K. Schilling, Kelley G. Hammond, Mark S. LeDoux, Ronald Pfeiffer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aims: Oxidative stress contributes to the pathogenesis of Parkinson's disease (PD). Recently, we reported that an eight week program of low volume, lower body resistance exercise training in PD is well tolerated and decreases oxidative stress. The present study was designed to examine the effects of a moderate volume and intensity total body resistance exercise program on biomarkers of oxidative stress in subjects with PD. Methods: Seventeen subjects with PD (12 men and 5 women; 65.2±2.0 yrs; Hoehn and Yahr stage I-III) completed a 12 week supervised resistance exercise training program. Exercise sessions were performed twice weekly, and consisted of three sets of 12 repetitions of the isolateral leg press, incline chest press, shoulder press, seated row and latissimus dorsi pulldown, as well as bilateral leg curl and calf press. Resting, fasting blood samples were taken from subjects before and after the intervention and were assayed for markers of oxidative stress [malondialdehyde (MDA), protein carbonyls (PC), and hydrogen peroxide (H2O2)] and antioxidant status [Trolox-Equivalent Antioxidant Capacity (TEAC)]. Results: The exercise program was well-tolerated and associated with a significant decrease (24%) in MDA (p=0.02), with a trend towards decreased PC (25%, p=0.09). Although a 12% reduction was noted in H2O2 from pre to post intervention, this change did not reach statistical significance. TEAC was unchanged by the intervention. Conclusions: Moderate volume and intensity resistance exercise training was well tolerated by patients with early to moderate stage PD and may be associated with decreased oxidative stress. Long-term interventions with larger sample sizes are needed to expand upon these findings.

Original languageEnglish (US)
Title of host publicationHandbook on Oxidative Stress New Research
PublisherNova Science Publishers, Inc.
Pages469-478
Number of pages10
ISBN (Print)9781619421783
StatePublished - 2012
Externally publishedYes

Fingerprint

Resistance Training
Parkinson Disease
Oxidative Stress
Biomarkers
Exercise
Antioxidants
Malondialdehyde
Leg
Superficial Back Muscles
Heat-Shock Proteins
Sample Size
Hydrogen Peroxide
Fasting
Thorax
Education
Proteins

Keywords

  • Antioxidants
  • Exercise
  • Neurological disease
  • Reactive oxygen species
  • Strength training

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bloomer, R. J., Schilling, B. K., Hammond, K. G., LeDoux, M. S., & Pfeiffer, R. (2012). Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease. In Handbook on Oxidative Stress New Research (pp. 469-478). Nova Science Publishers, Inc..

Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease. / Bloomer, Richard J.; Schilling, Brian K.; Hammond, Kelley G.; LeDoux, Mark S.; Pfeiffer, Ronald.

Handbook on Oxidative Stress New Research. Nova Science Publishers, Inc., 2012. p. 469-478.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bloomer, RJ, Schilling, BK, Hammond, KG, LeDoux, MS & Pfeiffer, R 2012, Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease. in Handbook on Oxidative Stress New Research. Nova Science Publishers, Inc., pp. 469-478.
Bloomer RJ, Schilling BK, Hammond KG, LeDoux MS, Pfeiffer R. Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease. In Handbook on Oxidative Stress New Research. Nova Science Publishers, Inc. 2012. p. 469-478
Bloomer, Richard J. ; Schilling, Brian K. ; Hammond, Kelley G. ; LeDoux, Mark S. ; Pfeiffer, Ronald. / Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease. Handbook on Oxidative Stress New Research. Nova Science Publishers, Inc., 2012. pp. 469-478
@inbook{cef1b4ed7e7a4dfc95db20765cbd32c8,
title = "Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease",
abstract = "Aims: Oxidative stress contributes to the pathogenesis of Parkinson's disease (PD). Recently, we reported that an eight week program of low volume, lower body resistance exercise training in PD is well tolerated and decreases oxidative stress. The present study was designed to examine the effects of a moderate volume and intensity total body resistance exercise program on biomarkers of oxidative stress in subjects with PD. Methods: Seventeen subjects with PD (12 men and 5 women; 65.2±2.0 yrs; Hoehn and Yahr stage I-III) completed a 12 week supervised resistance exercise training program. Exercise sessions were performed twice weekly, and consisted of three sets of 12 repetitions of the isolateral leg press, incline chest press, shoulder press, seated row and latissimus dorsi pulldown, as well as bilateral leg curl and calf press. Resting, fasting blood samples were taken from subjects before and after the intervention and were assayed for markers of oxidative stress [malondialdehyde (MDA), protein carbonyls (PC), and hydrogen peroxide (H2O2)] and antioxidant status [Trolox-Equivalent Antioxidant Capacity (TEAC)]. Results: The exercise program was well-tolerated and associated with a significant decrease (24{\%}) in MDA (p=0.02), with a trend towards decreased PC (25{\%}, p=0.09). Although a 12{\%} reduction was noted in H2O2 from pre to post intervention, this change did not reach statistical significance. TEAC was unchanged by the intervention. Conclusions: Moderate volume and intensity resistance exercise training was well tolerated by patients with early to moderate stage PD and may be associated with decreased oxidative stress. Long-term interventions with larger sample sizes are needed to expand upon these findings.",
keywords = "Antioxidants, Exercise, Neurological disease, Reactive oxygen species, Strength training",
author = "Bloomer, {Richard J.} and Schilling, {Brian K.} and Hammond, {Kelley G.} and LeDoux, {Mark S.} and Ronald Pfeiffer",
year = "2012",
language = "English (US)",
isbn = "9781619421783",
pages = "469--478",
booktitle = "Handbook on Oxidative Stress New Research",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Effect of resistance exercise training on biomarkers of oxidative stress in men and women with Parkinson's disease

AU - Bloomer, Richard J.

AU - Schilling, Brian K.

AU - Hammond, Kelley G.

AU - LeDoux, Mark S.

AU - Pfeiffer, Ronald

PY - 2012

Y1 - 2012

N2 - Aims: Oxidative stress contributes to the pathogenesis of Parkinson's disease (PD). Recently, we reported that an eight week program of low volume, lower body resistance exercise training in PD is well tolerated and decreases oxidative stress. The present study was designed to examine the effects of a moderate volume and intensity total body resistance exercise program on biomarkers of oxidative stress in subjects with PD. Methods: Seventeen subjects with PD (12 men and 5 women; 65.2±2.0 yrs; Hoehn and Yahr stage I-III) completed a 12 week supervised resistance exercise training program. Exercise sessions were performed twice weekly, and consisted of three sets of 12 repetitions of the isolateral leg press, incline chest press, shoulder press, seated row and latissimus dorsi pulldown, as well as bilateral leg curl and calf press. Resting, fasting blood samples were taken from subjects before and after the intervention and were assayed for markers of oxidative stress [malondialdehyde (MDA), protein carbonyls (PC), and hydrogen peroxide (H2O2)] and antioxidant status [Trolox-Equivalent Antioxidant Capacity (TEAC)]. Results: The exercise program was well-tolerated and associated with a significant decrease (24%) in MDA (p=0.02), with a trend towards decreased PC (25%, p=0.09). Although a 12% reduction was noted in H2O2 from pre to post intervention, this change did not reach statistical significance. TEAC was unchanged by the intervention. Conclusions: Moderate volume and intensity resistance exercise training was well tolerated by patients with early to moderate stage PD and may be associated with decreased oxidative stress. Long-term interventions with larger sample sizes are needed to expand upon these findings.

AB - Aims: Oxidative stress contributes to the pathogenesis of Parkinson's disease (PD). Recently, we reported that an eight week program of low volume, lower body resistance exercise training in PD is well tolerated and decreases oxidative stress. The present study was designed to examine the effects of a moderate volume and intensity total body resistance exercise program on biomarkers of oxidative stress in subjects with PD. Methods: Seventeen subjects with PD (12 men and 5 women; 65.2±2.0 yrs; Hoehn and Yahr stage I-III) completed a 12 week supervised resistance exercise training program. Exercise sessions were performed twice weekly, and consisted of three sets of 12 repetitions of the isolateral leg press, incline chest press, shoulder press, seated row and latissimus dorsi pulldown, as well as bilateral leg curl and calf press. Resting, fasting blood samples were taken from subjects before and after the intervention and were assayed for markers of oxidative stress [malondialdehyde (MDA), protein carbonyls (PC), and hydrogen peroxide (H2O2)] and antioxidant status [Trolox-Equivalent Antioxidant Capacity (TEAC)]. Results: The exercise program was well-tolerated and associated with a significant decrease (24%) in MDA (p=0.02), with a trend towards decreased PC (25%, p=0.09). Although a 12% reduction was noted in H2O2 from pre to post intervention, this change did not reach statistical significance. TEAC was unchanged by the intervention. Conclusions: Moderate volume and intensity resistance exercise training was well tolerated by patients with early to moderate stage PD and may be associated with decreased oxidative stress. Long-term interventions with larger sample sizes are needed to expand upon these findings.

KW - Antioxidants

KW - Exercise

KW - Neurological disease

KW - Reactive oxygen species

KW - Strength training

UR - http://www.scopus.com/inward/record.url?scp=84895840444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895840444&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84895840444

SN - 9781619421783

SP - 469

EP - 478

BT - Handbook on Oxidative Stress New Research

PB - Nova Science Publishers, Inc.

ER -