EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL

Monica Thacker Hinds; Steven A. Jones; B. Rita Alevriadou; Don P. Giddens

doi:10.1115/imece1998-0014

EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL

Monica Thacker Hinds, Steven A. Jones, B. Rita Alevriadou, Don P. Giddens

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile How conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile How with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.

Original language	English (US)
Title of host publication	Advances in Bioengineering
Publisher	American Society of Mechanical Engineers (ASME)
Pages	27-28
Number of pages	2
ISBN (Electronic)	9780791815823
DOIs	https://doi.org/10.1115/imece1998-0014
State	Published - 1998
Externally published	Yes
Event	ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998 - Anaheim, United States Duration: Nov 15 1998 → Nov 20 1998

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	1998-D

Conference

Conference	ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998
Country/Territory	United States
City	Anaheim
Period	11/15/98 → 11/20/98

ASJC Scopus subject areas

Mechanical Engineering

Access to Document

10.1115/imece1998-0014

Cite this

Hinds, M. T., Jones, S. A., Alevriadou, B. R., & Giddens, D. P. (1998). EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL. In Advances in Bioengineering (pp. 27-28). (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1998-D). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/imece1998-0014

EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL. / Hinds, Monica Thacker; Jones, Steven A.; Alevriadou, B. Rita et al.
Advances in Bioengineering. American Society of Mechanical Engineers (ASME), 1998. p. 27-28 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 1998-D).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hinds, MT, Jones, SA, Alevriadou, BR & Giddens, DP 1998, EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL. in Advances in Bioengineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 1998-D, American Society of Mechanical Engineers (ASME), pp. 27-28, ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998, Anaheim, United States, 11/15/98. https://doi.org/10.1115/imece1998-0014

Hinds MT, Jones SA, Alevriadou BR, Giddens DP. EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL. In Advances in Bioengineering. American Society of Mechanical Engineers (ASME). 1998. p. 27-28. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)). doi: 10.1115/imece1998-0014

Hinds, Monica Thacker ; Jones, Steven A. ; Alevriadou, B. Rita et al. / EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL. Advances in Bioengineering. American Society of Mechanical Engineers (ASME), 1998. pp. 27-28 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)).

@inproceedings{5d9e753c5e3c4f1badff5c87b5bfa1d9,

title = "EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL",

abstract = "We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile How conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile How with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.",

author = "Hinds, {Monica Thacker} and Jones, {Steven A.} and Alevriadou, {B. Rita} and Giddens, {Don P.}",

note = "Publisher Copyright: {\textcopyright} 1998 American Society of Mechanical Engineers (ASME). All rights reserved.; ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998 ; Conference date: 15-11-1998 Through 20-11-1998",

year = "1998",

doi = "10.1115/imece1998-0014",

language = "English (US)",

series = "ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)",

publisher = "American Society of Mechanical Engineers (ASME)",

pages = "27--28",

booktitle = "Advances in Bioengineering",

}

TY - GEN

T1 - EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL

AU - Hinds, Monica Thacker

AU - Jones, Steven A.

AU - Alevriadou, B. Rita

AU - Giddens, Don P.

PY - 1998

Y1 - 1998

N2 - We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile How conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile How with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.

AB - We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile How conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile How with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.

UR - http://www.scopus.com/inward/record.url?scp=85124422502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124422502&partnerID=8YFLogxK

U2 - 10.1115/imece1998-0014

DO - 10.1115/imece1998-0014

M3 - Conference contribution

AN - SCOPUS:85124422502

T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)

SP - 27

EP - 28

BT - Advances in Bioengineering

PB - American Society of Mechanical Engineers (ASME)

T2 - ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998

Y2 - 15 November 1998 through 20 November 1998

ER -

EFFECT OF PULSATILE FLOW ON MONOCYTIC CELL ADHESION TO E-SELECTIN COATED SURFACES OF A THREE-DIMENSIONAL PERFUSION MODEL

Abstract

Publication series

Conference

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this