Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model

Monica Hinds, B. Rita Alevriadou, Steven A. Jones, Don P. Giddens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile flow conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile flow with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Pages27-28
Number of pages2
Volume39
StatePublished - 1998
Externally publishedYes

Fingerprint

Pulsatile flow
Cell adhesion
Steady flow
Adhesion
Reynolds number
Cells
Selectins
Coatings
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hinds, M., Alevriadou, B. R., Jones, S. A., & Giddens, D. P. (1998). Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 39, pp. 27-28)

Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model. / Hinds, Monica; Alevriadou, B. Rita; Jones, Steven A.; Giddens, Don P.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 39 1998. p. 27-28.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hinds, M, Alevriadou, BR, Jones, SA & Giddens, DP 1998, Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 39, pp. 27-28.
Hinds M, Alevriadou BR, Jones SA, Giddens DP. Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 39. 1998. p. 27-28
Hinds, Monica ; Alevriadou, B. Rita ; Jones, Steven A. ; Giddens, Don P. / Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 39 1998. pp. 27-28
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