TY - JOUR
T1 - Effect of pulsatile flow on monocytic cell adhesion to E-selectin coated surfaces of a three-dimensional perfusion model
AU - Hinds, Monica Thacker
AU - Alevriadou, B. Rita
AU - Jones, Steven A.
AU - Giddens, Don P.
PY - 1998
Y1 - 1998
N2 - We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile flow conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile flow with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.
AB - We report on effects of pulsatile flow on monocytic cell adhesion to the surface of a model in which flow characteristics thought to be important in atherogenesis are simulated. The surface was coated with E-selectin, and adhesion of activated monocytes was investigated under pulsatile flow conditions and compared with uncoated models and steady flow experiments. Coating the model with E-selectin increased the adhesion of cells in all regions in the vertical model. However, pulsatile flow with the same mean Reynolds number as for steady flow significantly reduced the number of adherent cells throughout the model.
UR - http://www.scopus.com/inward/record.url?scp=0032302986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032302986&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032302986
SN - 1071-6947
VL - 39
SP - 27
EP - 28
JO - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
JF - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
ER -