Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans

Jean François Roux, Sattar Gojraty, Rupa Bala, Christopher F. Liu, Sanjay Dixit, Mathew D. Hutchinson, Fermin Garcia, David Lin, David J. Callans, Michael Riley, Francis Marchlinski, Edward P. Gerstenfeld

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Targeting of complex fractionated electrograms (CFEs) has been used as an adjunctive strategy to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). However, it is unclear whether CFEs should be targeted before or after PVI. Objectives: The purpose of this study was to examine the effect of PVI on CFE distribution in humans. Methods: We compared left atrial (LA) CFE maps acquired using the NavX system before and after PVI in patients with persistent AF. CFE maps were constructed from bipolar electrograms acquired from a circular mapping catheter. At each point, the mean AF cycle length (CL) was calculated automatically by averaging the intervals between deflections over a 4-second window. Sites with mean CL ≤120 ms were considered CFE+. Results: A total of 22 consecutive patients (82% male, age 58 ± 9 years) were studied. At baseline, 47% of the LA was encompassed by electrograms with CL

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalHeart Rhythm
Volume6
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Pulmonary Veins
Patient Isolation
Atrial Fibrillation
Catheters

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Complex fractionated atrial electrograms
  • Pulmonary veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Roux, J. F., Gojraty, S., Bala, R., Liu, C. F., Dixit, S., Hutchinson, M. D., ... Gerstenfeld, E. P. (2009). Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans. Heart Rhythm, 6(2), 156-160. https://doi.org/10.1016/j.hrthm.2008.10.046

Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans. / Roux, Jean François; Gojraty, Sattar; Bala, Rupa; Liu, Christopher F.; Dixit, Sanjay; Hutchinson, Mathew D.; Garcia, Fermin; Lin, David; Callans, David J.; Riley, Michael; Marchlinski, Francis; Gerstenfeld, Edward P.

In: Heart Rhythm, Vol. 6, No. 2, 02.2009, p. 156-160.

Research output: Contribution to journalArticle

Roux, JF, Gojraty, S, Bala, R, Liu, CF, Dixit, S, Hutchinson, MD, Garcia, F, Lin, D, Callans, DJ, Riley, M, Marchlinski, F & Gerstenfeld, EP 2009, 'Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans', Heart Rhythm, vol. 6, no. 2, pp. 156-160. https://doi.org/10.1016/j.hrthm.2008.10.046
Roux, Jean François ; Gojraty, Sattar ; Bala, Rupa ; Liu, Christopher F. ; Dixit, Sanjay ; Hutchinson, Mathew D. ; Garcia, Fermin ; Lin, David ; Callans, David J. ; Riley, Michael ; Marchlinski, Francis ; Gerstenfeld, Edward P. / Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans. In: Heart Rhythm. 2009 ; Vol. 6, No. 2. pp. 156-160.
@article{adac1bd3e9e340919d7be8509c15d9da,
title = "Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans",
abstract = "Background: Targeting of complex fractionated electrograms (CFEs) has been used as an adjunctive strategy to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). However, it is unclear whether CFEs should be targeted before or after PVI. Objectives: The purpose of this study was to examine the effect of PVI on CFE distribution in humans. Methods: We compared left atrial (LA) CFE maps acquired using the NavX system before and after PVI in patients with persistent AF. CFE maps were constructed from bipolar electrograms acquired from a circular mapping catheter. At each point, the mean AF cycle length (CL) was calculated automatically by averaging the intervals between deflections over a 4-second window. Sites with mean CL ≤120 ms were considered CFE+. Results: A total of 22 consecutive patients (82{\%} male, age 58 ± 9 years) were studied. At baseline, 47{\%} of the LA was encompassed by electrograms with CL",
keywords = "Atrial fibrillation, Catheter ablation, Complex fractionated atrial electrograms, Pulmonary veins",
author = "Roux, {Jean Fran{\cc}ois} and Sattar Gojraty and Rupa Bala and Liu, {Christopher F.} and Sanjay Dixit and Hutchinson, {Mathew D.} and Fermin Garcia and David Lin and Callans, {David J.} and Michael Riley and Francis Marchlinski and Gerstenfeld, {Edward P.}",
year = "2009",
month = "2",
doi = "10.1016/j.hrthm.2008.10.046",
language = "English (US)",
volume = "6",
pages = "156--160",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans

AU - Roux, Jean François

AU - Gojraty, Sattar

AU - Bala, Rupa

AU - Liu, Christopher F.

AU - Dixit, Sanjay

AU - Hutchinson, Mathew D.

AU - Garcia, Fermin

AU - Lin, David

AU - Callans, David J.

AU - Riley, Michael

AU - Marchlinski, Francis

AU - Gerstenfeld, Edward P.

PY - 2009/2

Y1 - 2009/2

N2 - Background: Targeting of complex fractionated electrograms (CFEs) has been used as an adjunctive strategy to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). However, it is unclear whether CFEs should be targeted before or after PVI. Objectives: The purpose of this study was to examine the effect of PVI on CFE distribution in humans. Methods: We compared left atrial (LA) CFE maps acquired using the NavX system before and after PVI in patients with persistent AF. CFE maps were constructed from bipolar electrograms acquired from a circular mapping catheter. At each point, the mean AF cycle length (CL) was calculated automatically by averaging the intervals between deflections over a 4-second window. Sites with mean CL ≤120 ms were considered CFE+. Results: A total of 22 consecutive patients (82% male, age 58 ± 9 years) were studied. At baseline, 47% of the LA was encompassed by electrograms with CL

AB - Background: Targeting of complex fractionated electrograms (CFEs) has been used as an adjunctive strategy to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). However, it is unclear whether CFEs should be targeted before or after PVI. Objectives: The purpose of this study was to examine the effect of PVI on CFE distribution in humans. Methods: We compared left atrial (LA) CFE maps acquired using the NavX system before and after PVI in patients with persistent AF. CFE maps were constructed from bipolar electrograms acquired from a circular mapping catheter. At each point, the mean AF cycle length (CL) was calculated automatically by averaging the intervals between deflections over a 4-second window. Sites with mean CL ≤120 ms were considered CFE+. Results: A total of 22 consecutive patients (82% male, age 58 ± 9 years) were studied. At baseline, 47% of the LA was encompassed by electrograms with CL

KW - Atrial fibrillation

KW - Catheter ablation

KW - Complex fractionated atrial electrograms

KW - Pulmonary veins

UR - http://www.scopus.com/inward/record.url?scp=58849138460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849138460&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2008.10.046

DO - 10.1016/j.hrthm.2008.10.046

M3 - Article

VL - 6

SP - 156

EP - 160

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 2

ER -