Effect of proteins on the immunogenicity of enterobacterial common antigen

H. M. Kuhn, Grazyna Adamus, E. Romanowska, H. Mayer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Enterobacterial common antigen isolated by two independent extraction procedures was found to precipiate with a number of basic or hydrophobic proteins. Complexes of enterobacterial common antigen with protamine sulfate, with methylated bovine serum albumin or with a fraction of outer membrane proteins of two different Shigella wild types proved to be highly immunogenic in rabbits upon intravenous immunization, in contrast to the enterobacterial common antigen preparations by themselves. This explains why crude isolates of entero-bacterial common antigen usually are good immunogens in contrast to the isolated antigen, which was described to be either not or only very poorly immunogenic.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalInfection and Immunity
Volume34
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

Bacterial Antigens
Proteins
Protamines
Shigella
Immunization
Membrane Proteins
Rabbits
Antigens
enterobacterial common antigen
methylated bovine serum albumin

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of proteins on the immunogenicity of enterobacterial common antigen. / Kuhn, H. M.; Adamus, Grazyna; Romanowska, E.; Mayer, H.

In: Infection and Immunity, Vol. 34, No. 2, 1981, p. 373-377.

Research output: Contribution to journalArticle

Kuhn, HM, Adamus, G, Romanowska, E & Mayer, H 1981, 'Effect of proteins on the immunogenicity of enterobacterial common antigen', Infection and Immunity, vol. 34, no. 2, pp. 373-377.
Kuhn, H. M. ; Adamus, Grazyna ; Romanowska, E. ; Mayer, H. / Effect of proteins on the immunogenicity of enterobacterial common antigen. In: Infection and Immunity. 1981 ; Vol. 34, No. 2. pp. 373-377.
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