Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis

Halina Offner, Bente Danneskiold-Samsøe, Paula Dore-Duffy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalClinical Immunology and Immunopathology
Volume22
Issue number2
DOIs
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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