Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis

Halina Offner; Bente Danneskiold-Samsøe; Paula Dore-Duffy

doi:10.1016/0090-1229(82)90034-4

Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis

Halina Offner, Bente Danneskiold-Samsøe, Paula Dore-Duffy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E₁ and E₂ (10^-4 and 10^-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.

Original language	English (US)
Pages (from-to)	159-167
Number of pages	9
Journal	Clinical Immunology and Immunopathology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(82)90034-4
State	Published - Feb 1982
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(82)90034-4

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title = "Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis",

abstract = "Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.",

author = "Halina Offner and Bente Danneskiold-Sams{\o}e and Paula Dore-Duffy",

note = "Funding Information: The authors acknowledge Barbara S. Rothman for expert technical typing. and Dr. Robert B. Zurier for his advice and encouragement. by a grant from the National Multiple Sclerosis Society. a grant Research Grant NS-14357 from the National Institutes of Health.",

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AU - Dore-Duffy, Paula

N1 - Funding Information: The authors acknowledge Barbara S. Rothman for expert technical typing. and Dr. Robert B. Zurier for his advice and encouragement. by a grant from the National Multiple Sclerosis Society. a grant Research Grant NS-14357 from the National Institutes of Health.

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AB - Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.

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Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis

Abstract

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