Abstract
Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-167 |
| Number of pages | 9 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1982 |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology
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Offner, H., Danneskiold-Samsøe, B., & Dore-Duffy, P. (1982). Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis. Clinical Immunology and Immunopathology, 22(2), 159-167. https://doi.org/10.1016/0090-1229(82)90034-4