TY - JOUR
T1 - Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis
AU - Offner, Halina
AU - Danneskiold-Samsøe, Bente
AU - Dore-Duffy, Paula
N1 - Funding Information:
The authors acknowledge Barbara S. Rothman for expert technical typing. and Dr. Robert B. Zurier for his advice and encouragement. by a grant from the National Multiple Sclerosis Society. a grant Research Grant NS-14357 from the National Institutes of Health.
PY - 1982/2
Y1 - 1982/2
N2 - Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.
AB - Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.
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U2 - 10.1016/0090-1229(82)90034-4
DO - 10.1016/0090-1229(82)90034-4
M3 - Article
C2 - 6286189
AN - SCOPUS:0020082448
SN - 0090-1229
VL - 22
SP - 159
EP - 167
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -