Abstract
Active E-rosette-forming lymphocytes were examined in patients with multiple sclerosis, patients with other neurological diseases, and patients with rheumatoid arthritis. Significantly fewer (P < 0.01) active E rosettes were found in multiple sclerosis and RA patients than in controls. The lower levels of active E rosettes in MS could be enhanced by physiological levels of prostaglandins E1 and E2 (10-4 and 10-11 M). MS patients appar to have a circulating population of immature E-rosetting lymphocytes sensitive to modulation with prostaglandin E.
Original language | English (US) |
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Pages (from-to) | 159-167 |
Number of pages | 9 |
Journal | Clinical Immunology and Immunopathology |
Volume | 22 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology