Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas

T. T K Jung, Y. M. Park, D. Schlund, Douglas Weeks, S. Miller, O. Wong, S. K. Juhn

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Although previous studies have shown that prostaglandins (PGs), leukotrienes (LTs), and other arachidonic acid (AA) metabolites play an important role in the pathogenesis of otitis media with effusion (OME), the exact role of each AA metabolite in OME is still unknown. The purpose of this study was to examine the effect of several individual AA metabolites alone or in combination and AA itself on experimental otitis media in chinchillas. Normal chinchillas were inoculated daily with normal saline PGE2, LTC4 + PGE2, and AA through the superior bullae over 7 days. Animals were followed by otoscopy and tympanometry, samples of middle ear effusion were collected for biochemical assay, and temporal bones were processed for histopathology. The highest number of ears that developed OME was in the group inoculated with PGE2 + LTC4. The degree of inflammatory change was more pronounced in groups injected with LTC4 that any other group. The findings of this study suggest that eicosanoids PGE2, LTC4, and AA alone or in combination inoculated into the middle ear can induce OME.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume99
Issue number6 II SUPPL. 148
StatePublished - 1990
Externally publishedYes

Fingerprint

Chinchilla
Otitis Media with Effusion
Leukotrienes
Arachidonic Acid
Prostaglandins
Leukotriene C4
Dinoprostone
Otoscopy
Acoustic Impedance Tests
Eicosanoids
Temporal Bone
Otitis Media
Middle Ear
Blister
Ear

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Jung, T. T. K., Park, Y. M., Schlund, D., Weeks, D., Miller, S., Wong, O., & Juhn, S. K. (1990). Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas. Annals of Otology, Rhinology and Laryngology, 99(6 II SUPPL. 148), 28-32.

Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas. / Jung, T. T K; Park, Y. M.; Schlund, D.; Weeks, Douglas; Miller, S.; Wong, O.; Juhn, S. K.

In: Annals of Otology, Rhinology and Laryngology, Vol. 99, No. 6 II SUPPL. 148, 1990, p. 28-32.

Research output: Contribution to journalArticle

Jung, TTK, Park, YM, Schlund, D, Weeks, D, Miller, S, Wong, O & Juhn, SK 1990, 'Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas', Annals of Otology, Rhinology and Laryngology, vol. 99, no. 6 II SUPPL. 148, pp. 28-32.
Jung, T. T K ; Park, Y. M. ; Schlund, D. ; Weeks, Douglas ; Miller, S. ; Wong, O. ; Juhn, S. K. / Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas. In: Annals of Otology, Rhinology and Laryngology. 1990 ; Vol. 99, No. 6 II SUPPL. 148. pp. 28-32.
@article{531409c5f439410389a65245e16c7242,
title = "Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas",
abstract = "Although previous studies have shown that prostaglandins (PGs), leukotrienes (LTs), and other arachidonic acid (AA) metabolites play an important role in the pathogenesis of otitis media with effusion (OME), the exact role of each AA metabolite in OME is still unknown. The purpose of this study was to examine the effect of several individual AA metabolites alone or in combination and AA itself on experimental otitis media in chinchillas. Normal chinchillas were inoculated daily with normal saline PGE2, LTC4 + PGE2, and AA through the superior bullae over 7 days. Animals were followed by otoscopy and tympanometry, samples of middle ear effusion were collected for biochemical assay, and temporal bones were processed for histopathology. The highest number of ears that developed OME was in the group inoculated with PGE2 + LTC4. The degree of inflammatory change was more pronounced in groups injected with LTC4 that any other group. The findings of this study suggest that eicosanoids PGE2, LTC4, and AA alone or in combination inoculated into the middle ear can induce OME.",
author = "Jung, {T. T K} and Park, {Y. M.} and D. Schlund and Douglas Weeks and S. Miller and O. Wong and Juhn, {S. K.}",
year = "1990",
language = "English (US)",
volume = "99",
pages = "28--32",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "6 II SUPPL. 148",

}

TY - JOUR

T1 - Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas

AU - Jung, T. T K

AU - Park, Y. M.

AU - Schlund, D.

AU - Weeks, Douglas

AU - Miller, S.

AU - Wong, O.

AU - Juhn, S. K.

PY - 1990

Y1 - 1990

N2 - Although previous studies have shown that prostaglandins (PGs), leukotrienes (LTs), and other arachidonic acid (AA) metabolites play an important role in the pathogenesis of otitis media with effusion (OME), the exact role of each AA metabolite in OME is still unknown. The purpose of this study was to examine the effect of several individual AA metabolites alone or in combination and AA itself on experimental otitis media in chinchillas. Normal chinchillas were inoculated daily with normal saline PGE2, LTC4 + PGE2, and AA through the superior bullae over 7 days. Animals were followed by otoscopy and tympanometry, samples of middle ear effusion were collected for biochemical assay, and temporal bones were processed for histopathology. The highest number of ears that developed OME was in the group inoculated with PGE2 + LTC4. The degree of inflammatory change was more pronounced in groups injected with LTC4 that any other group. The findings of this study suggest that eicosanoids PGE2, LTC4, and AA alone or in combination inoculated into the middle ear can induce OME.

AB - Although previous studies have shown that prostaglandins (PGs), leukotrienes (LTs), and other arachidonic acid (AA) metabolites play an important role in the pathogenesis of otitis media with effusion (OME), the exact role of each AA metabolite in OME is still unknown. The purpose of this study was to examine the effect of several individual AA metabolites alone or in combination and AA itself on experimental otitis media in chinchillas. Normal chinchillas were inoculated daily with normal saline PGE2, LTC4 + PGE2, and AA through the superior bullae over 7 days. Animals were followed by otoscopy and tympanometry, samples of middle ear effusion were collected for biochemical assay, and temporal bones were processed for histopathology. The highest number of ears that developed OME was in the group inoculated with PGE2 + LTC4. The degree of inflammatory change was more pronounced in groups injected with LTC4 that any other group. The findings of this study suggest that eicosanoids PGE2, LTC4, and AA alone or in combination inoculated into the middle ear can induce OME.

UR - http://www.scopus.com/inward/record.url?scp=0025357995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025357995&partnerID=8YFLogxK

M3 - Article

C2 - 2161636

AN - SCOPUS:0025357995

VL - 99

SP - 28

EP - 32

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 6 II SUPPL. 148

ER -