Effect of prostaglandin I2 on ovine placental vasculature

J. H G Rankin, T. M. Phernetton, Debra Anderson, A. D. Berssenbrugge

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The response of the placental circulations to prostaglandin I2 (maternal dose 20 μg/kg, fetal dose 180 μg/kg) was observed in 10 near-term sheep with chronically implanted vascular catheters. The blood flows before and 90 s after the injection of prostaglandin I2 were measured using radioactive microspheres. The injection of prostaglandin I2 to the mother decreased the blood pressure from 109±4 to 69±5 mmHg (P<0.001) and increased the vascular resistance of the maternal cytoledons from 0.166±0.018 to 0.209±0.02 mmHg (ml/min) (P<0.001). The vascular bed of the non-cotyledonary uterus vasodilated as the resistance fell from 0.705±0.02 to 0.266±0.02 mmHg/(ml/min) (P<0.001). Prostaglandin I2 caused the fetal arteriovenous pressure to fall from 37.6±1.35 to 26.0±1.6 mmHg. There was no significant change in the vascular resistance of the fetal cotyledons. We observed vasodilation in the fetal membranes as vascular resistance fell from 1.06±0.14 to 0.75±0.10 mmHg/(ml/min) (P<0.001). The infusion of prostaglandin I2 significantly depressed the response of the placenta and uterus to norepinephrine. We have not proved that prostaglandin I2 plays a direct role in maintaining placental vascular homeostasis but it may modulate the response of this organ to exogenous vasoactive agents.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalJournal of Developmental Physiology
Volume1
Issue number2
StatePublished - 1979
Externally publishedYes

Fingerprint

Epoprostenol
Sheep
Vascular Resistance
Uterus
Blood Vessels
Mothers
Placental Circulation
Extraembryonic Membranes
Vascular Access Devices
Injections
Cotyledon
Microspheres
Vasodilation
Placenta
Norepinephrine
Homeostasis
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Rankin, J. H. G., Phernetton, T. M., Anderson, D., & Berssenbrugge, A. D. (1979). Effect of prostaglandin I2 on ovine placental vasculature. Journal of Developmental Physiology, 1(2), 151-160.

Effect of prostaglandin I2 on ovine placental vasculature. / Rankin, J. H G; Phernetton, T. M.; Anderson, Debra; Berssenbrugge, A. D.

In: Journal of Developmental Physiology, Vol. 1, No. 2, 1979, p. 151-160.

Research output: Contribution to journalArticle

Rankin, JHG, Phernetton, TM, Anderson, D & Berssenbrugge, AD 1979, 'Effect of prostaglandin I2 on ovine placental vasculature', Journal of Developmental Physiology, vol. 1, no. 2, pp. 151-160.
Rankin JHG, Phernetton TM, Anderson D, Berssenbrugge AD. Effect of prostaglandin I2 on ovine placental vasculature. Journal of Developmental Physiology. 1979;1(2):151-160.
Rankin, J. H G ; Phernetton, T. M. ; Anderson, Debra ; Berssenbrugge, A. D. / Effect of prostaglandin I2 on ovine placental vasculature. In: Journal of Developmental Physiology. 1979 ; Vol. 1, No. 2. pp. 151-160.
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