Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Jennifer L. Lycette; Carrie L. Dul; Myrna Munar; Donna Belle; Stephen Y. Chui; Dennis R. Koop; Craig R. Nichols

doi:10.3816/CBC.2006.n.049

Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Jennifer L. Lycette, Carrie L. Dul, Myrna Munar, Donna Belle, Stephen Y. Chui, Dennis R. Koop, Craig R. Nichols

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.

Original language	English (US)
Pages (from-to)	342-344
Number of pages	3
Journal	Clinical Breast Cancer
Volume	7
Issue number	4
DOIs	https://doi.org/10.3816/CBC.2006.n.049
State	Published - Oct 2006

Keywords

Chemotherapy
Dose-dense therapy
Taxanes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3816/CBC.2006.n.049

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abstract = "Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.",

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AU - Lycette, Jennifer L.

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AU - Munar, Myrna

AU - Belle, Donna

AU - Chui, Stephen Y.

AU - Koop, Dennis R.

AU - Nichols, Craig R.

PY - 2006/10

Y1 - 2006/10

N2 - Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.

AB - Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.

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KW - Dose-dense therapy

KW - Taxanes

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Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Abstract

Keywords

ASJC Scopus subject areas

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