Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Jennifer Lycette, Carrie L. Dul, Myrna Munar, Donna Belle, Stephen (Steve) Chui, Dennis Koop, Craig R. Nichols

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.

Original languageEnglish (US)
Pages (from-to)342-344
Number of pages3
JournalClinical Breast Cancer
Volume7
Issue number4
DOIs
Publication statusPublished - 2006

Keywords

  • Chemotherapy
  • Dose-dense therapy
  • Taxanes

ASJC Scopus subject areas

  • Cancer Research

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