EFFECT OF PHYTOHEMAGGLUTININ, BASIC PROTEIN AND MEASLES ANTIGEN ON MYO‐(2‐3H)INOSITOL INCORPORATION INTO PHOSPHATIDYLINOSITOL OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS

H. Offner; G. Konat; J. Clausen

doi:10.1111/j.1600-0404.1974.tb02819.x

EFFECT OF PHYTOHEMAGGLUTININ, BASIC PROTEIN AND MEASLES ANTIGEN ON MYO‐(2‐³H)INOSITOL INCORPORATION INTO PHOSPHATIDYLINOSITOL OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS

H. Offner, G. Konat, J. Clausen

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The incorporation of myo‐(2‐³H)inositol into phosphatidylinositol pre‐sent in lymphocytes from multiple sclerosis (MS) patients and control patients was assayed. The lymphocytes were in vitro prior to an assay stimulated with phytohemagglutinin (PHA), basic protein (BP) and measles antigen (MA). MS patients revealed lower incorporation of myo‐(2‐³H)inositol into the monophosphatidylinositol fraction than controls when stimulated with PHA (P < 0.025) and MA (P < 0.005). Three of the MS patients studied appeared to have a response to BP which was higher than the mean value plus the SD value of the MS group.

Original language	English (US)
Pages (from-to)	791-800
Number of pages	10
Journal	Acta Neurologica Scandinavica
Volume	50
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0404.1974.tb02819.x
State	Published - Dec 1974
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "EFFECT OF PHYTOHEMAGGLUTININ, BASIC PROTEIN AND MEASLES ANTIGEN ON MYO‐(2‐3H)INOSITOL INCORPORATION INTO PHOSPHATIDYLINOSITOL OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS",

abstract = "The incorporation of myo‐(2‐3H)inositol into phosphatidylinositol pre‐sent in lymphocytes from multiple sclerosis (MS) patients and control patients was assayed. The lymphocytes were in vitro prior to an assay stimulated with phytohemagglutinin (PHA), basic protein (BP) and measles antigen (MA). MS patients revealed lower incorporation of myo‐(2‐3H)inositol into the monophosphatidylinositol fraction than controls when stimulated with PHA (P < 0.025) and MA (P < 0.005). Three of the MS patients studied appeared to have a response to BP which was higher than the mean value plus the SD value of the MS group.",

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year = "1974",

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AU - Offner, H.

AU - Konat, G.

AU - Clausen, J.

PY - 1974/12

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AB - The incorporation of myo‐(2‐3H)inositol into phosphatidylinositol pre‐sent in lymphocytes from multiple sclerosis (MS) patients and control patients was assayed. The lymphocytes were in vitro prior to an assay stimulated with phytohemagglutinin (PHA), basic protein (BP) and measles antigen (MA). MS patients revealed lower incorporation of myo‐(2‐3H)inositol into the monophosphatidylinositol fraction than controls when stimulated with PHA (P < 0.025) and MA (P < 0.005). Three of the MS patients studied appeared to have a response to BP which was higher than the mean value plus the SD value of the MS group.

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EFFECT OF PHYTOHEMAGGLUTININ, BASIC PROTEIN AND MEASLES ANTIGEN ON MYO‐(2‐³H)INOSITOL INCORPORATION INTO PHOSPHATIDYLINOSITOL OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS

Abstract

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