Effect of photodynamic therapy on the critical primary ischemic time of fasciocutaneous flaps

Michael J. Belmont, Nicole Marabelle, Thomas S. Mang, Mark Wax

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Photodynamic therapy (PDT) may be used as an adjuvant intraoperative therapy to improve locoregional control. PDT has been shown to delay wound healing. This raises concern about PDT's effect on survival of fasciocutaneous flaps. Objective: Evaluate the effect of 1) PDT on the critical ischemic time in a rat fasciocutaneous flap model and 2) photosensitizer activation by the surgical light source. Design: A fasciocutaneous flap, based on the left inferior epigastric vessels, was used. Ischemic times of 2, 4, 6, 8, 10, and 12 hours were induced by clamping the vascular pedicle. Animals were randomly divided into five groups: ischemia only, group I; light treatment to wound bed, group H; Photofrin before surgery with the flap elevated without a fiber optic head light, group III, or with a headlight, group IV; Photofrin prior to surgery with light treatment to the wound bed, group V. Flap survival was assessed on postoperative day 7. Results: The critical primary ischemic time of group V (PDT) was significantly less (P <.05) than groups I, II, III, and IV. There was no statistical difference in the critical primary ischemic time when a fiber optic headlight was used (group HI vs. group IV). Conclusion: Intraoperative PDT significantly reduces the critical primary ischemic time of the rat fasciocutaneous flap. White light illumination of the operative field does not result in photosensitizer activation and has no effect on the critical primary ischemic time.

Original languageEnglish (US)
Pages (from-to)886-890
Number of pages5
JournalLaryngoscope
Volume109
Issue number6
DOIs
StatePublished - Jun 1999

Fingerprint

Photochemotherapy
Light
Dihematoporphyrin Ether
Photosensitizing Agents
Wounds and Injuries
Lighting
Constriction
Wound Healing
Blood Vessels
Therapeutics
Ischemia
Head

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effect of photodynamic therapy on the critical primary ischemic time of fasciocutaneous flaps. / Belmont, Michael J.; Marabelle, Nicole; Mang, Thomas S.; Wax, Mark.

In: Laryngoscope, Vol. 109, No. 6, 06.1999, p. 886-890.

Research output: Contribution to journalArticle

Belmont, Michael J. ; Marabelle, Nicole ; Mang, Thomas S. ; Wax, Mark. / Effect of photodynamic therapy on the critical primary ischemic time of fasciocutaneous flaps. In: Laryngoscope. 1999 ; Vol. 109, No. 6. pp. 886-890.
@article{7bed47cc1bc54ed989f836859fe036f4,
title = "Effect of photodynamic therapy on the critical primary ischemic time of fasciocutaneous flaps",
abstract = "Background: Photodynamic therapy (PDT) may be used as an adjuvant intraoperative therapy to improve locoregional control. PDT has been shown to delay wound healing. This raises concern about PDT's effect on survival of fasciocutaneous flaps. Objective: Evaluate the effect of 1) PDT on the critical ischemic time in a rat fasciocutaneous flap model and 2) photosensitizer activation by the surgical light source. Design: A fasciocutaneous flap, based on the left inferior epigastric vessels, was used. Ischemic times of 2, 4, 6, 8, 10, and 12 hours were induced by clamping the vascular pedicle. Animals were randomly divided into five groups: ischemia only, group I; light treatment to wound bed, group H; Photofrin before surgery with the flap elevated without a fiber optic head light, group III, or with a headlight, group IV; Photofrin prior to surgery with light treatment to the wound bed, group V. Flap survival was assessed on postoperative day 7. Results: The critical primary ischemic time of group V (PDT) was significantly less (P <.05) than groups I, II, III, and IV. There was no statistical difference in the critical primary ischemic time when a fiber optic headlight was used (group HI vs. group IV). Conclusion: Intraoperative PDT significantly reduces the critical primary ischemic time of the rat fasciocutaneous flap. White light illumination of the operative field does not result in photosensitizer activation and has no effect on the critical primary ischemic time.",
author = "Belmont, {Michael J.} and Nicole Marabelle and Mang, {Thomas S.} and Mark Wax",
year = "1999",
month = "6",
doi = "10.1097/00005537-199906000-00008",
language = "English (US)",
volume = "109",
pages = "886--890",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Effect of photodynamic therapy on the critical primary ischemic time of fasciocutaneous flaps

AU - Belmont, Michael J.

AU - Marabelle, Nicole

AU - Mang, Thomas S.

AU - Wax, Mark

PY - 1999/6

Y1 - 1999/6

N2 - Background: Photodynamic therapy (PDT) may be used as an adjuvant intraoperative therapy to improve locoregional control. PDT has been shown to delay wound healing. This raises concern about PDT's effect on survival of fasciocutaneous flaps. Objective: Evaluate the effect of 1) PDT on the critical ischemic time in a rat fasciocutaneous flap model and 2) photosensitizer activation by the surgical light source. Design: A fasciocutaneous flap, based on the left inferior epigastric vessels, was used. Ischemic times of 2, 4, 6, 8, 10, and 12 hours were induced by clamping the vascular pedicle. Animals were randomly divided into five groups: ischemia only, group I; light treatment to wound bed, group H; Photofrin before surgery with the flap elevated without a fiber optic head light, group III, or with a headlight, group IV; Photofrin prior to surgery with light treatment to the wound bed, group V. Flap survival was assessed on postoperative day 7. Results: The critical primary ischemic time of group V (PDT) was significantly less (P <.05) than groups I, II, III, and IV. There was no statistical difference in the critical primary ischemic time when a fiber optic headlight was used (group HI vs. group IV). Conclusion: Intraoperative PDT significantly reduces the critical primary ischemic time of the rat fasciocutaneous flap. White light illumination of the operative field does not result in photosensitizer activation and has no effect on the critical primary ischemic time.

AB - Background: Photodynamic therapy (PDT) may be used as an adjuvant intraoperative therapy to improve locoregional control. PDT has been shown to delay wound healing. This raises concern about PDT's effect on survival of fasciocutaneous flaps. Objective: Evaluate the effect of 1) PDT on the critical ischemic time in a rat fasciocutaneous flap model and 2) photosensitizer activation by the surgical light source. Design: A fasciocutaneous flap, based on the left inferior epigastric vessels, was used. Ischemic times of 2, 4, 6, 8, 10, and 12 hours were induced by clamping the vascular pedicle. Animals were randomly divided into five groups: ischemia only, group I; light treatment to wound bed, group H; Photofrin before surgery with the flap elevated without a fiber optic head light, group III, or with a headlight, group IV; Photofrin prior to surgery with light treatment to the wound bed, group V. Flap survival was assessed on postoperative day 7. Results: The critical primary ischemic time of group V (PDT) was significantly less (P <.05) than groups I, II, III, and IV. There was no statistical difference in the critical primary ischemic time when a fiber optic headlight was used (group HI vs. group IV). Conclusion: Intraoperative PDT significantly reduces the critical primary ischemic time of the rat fasciocutaneous flap. White light illumination of the operative field does not result in photosensitizer activation and has no effect on the critical primary ischemic time.

UR - http://www.scopus.com/inward/record.url?scp=0033037068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033037068&partnerID=8YFLogxK

U2 - 10.1097/00005537-199906000-00008

DO - 10.1097/00005537-199906000-00008

M3 - Article

C2 - 10369276

AN - SCOPUS:0033037068

VL - 109

SP - 886

EP - 890

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 6

ER -