Effect of photodynamic therapy on revascularization of fasciocutaneous flaps

Michael J. Belmont, Nicole Marabelle, Thomas S. Mang, Richard Hall, Mark Wax

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Photodynamic therapy (PDT) may be used as an adjuvant intraoperative treatment to improve locoregional control. PDT has been shown both to delay wound healing and to have a deleterious effect on flap survival after a primary ischemic insult. This delay in wound healing may make the flap dependent on its pedicled blood supply for a prolonged period. Long-term flap loss may be experienced. The effect of PDT on flap revascularization, with subsequent dependence on its vascular pedicle, is evaluated. Study Design: Randomized controlled trial using a rodent model. Methods: A rat fasciocutaneous flap was used. Study groups were as follows: group I received no treatment; group II received treatment with 630-nm light; groups III and IV were given Photofrin (in group III, loupes without a fiberoptic light source were used for flap elevation, and in group IV, light source was employed); and group V was given Photofrin and 630-nm light. Primary ischemic times of 2 or 4 hours were used. Vascular pedicles were ligated on postoperative day (POD) 5, 6, or 7, and percentage of flap survival was evaluated 7 days later. Results: With 2 hours of ischemia, revascularization was decreased in the PDT group on POD 6 (P <.05) and on day 7 (P <.005) when compared with the other groups. With 4 hours of ischemia, revascularization was decreased in the PDT group on PODs 5 (P <.001), 6 (P <.01), and 7 (P <.005). Conclusion: Intraoperative PDT decreases revascularization of a rat fasciocutaneous flap.

Original languageEnglish (US)
Pages (from-to)942-945
Number of pages4
JournalLaryngoscope
Volume110
Issue number6
StatePublished - Jun 2000

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Photochemotherapy
Dihematoporphyrin Ether
Light
Wound Healing
Blood Vessels
Ischemia
Rodentia
Therapeutics
Randomized Controlled Trials

Keywords

  • Fasciocutaneous
  • Flap
  • Photodynamic therapy
  • Revascularization

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Belmont, M. J., Marabelle, N., Mang, T. S., Hall, R., & Wax, M. (2000). Effect of photodynamic therapy on revascularization of fasciocutaneous flaps. Laryngoscope, 110(6), 942-945.

Effect of photodynamic therapy on revascularization of fasciocutaneous flaps. / Belmont, Michael J.; Marabelle, Nicole; Mang, Thomas S.; Hall, Richard; Wax, Mark.

In: Laryngoscope, Vol. 110, No. 6, 06.2000, p. 942-945.

Research output: Contribution to journalArticle

Belmont, MJ, Marabelle, N, Mang, TS, Hall, R & Wax, M 2000, 'Effect of photodynamic therapy on revascularization of fasciocutaneous flaps', Laryngoscope, vol. 110, no. 6, pp. 942-945.
Belmont MJ, Marabelle N, Mang TS, Hall R, Wax M. Effect of photodynamic therapy on revascularization of fasciocutaneous flaps. Laryngoscope. 2000 Jun;110(6):942-945.
Belmont, Michael J. ; Marabelle, Nicole ; Mang, Thomas S. ; Hall, Richard ; Wax, Mark. / Effect of photodynamic therapy on revascularization of fasciocutaneous flaps. In: Laryngoscope. 2000 ; Vol. 110, No. 6. pp. 942-945.
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