Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque

Steven Kohama, Lauren Renner, Noelle Landauer, Alison R. Weiss, Henryk Urbanski, Byung Park, Mary Lou Voytko, Martha Neuringer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Studies of the effect of hormone therapy on cognitive function in menopausalwomenhave been equivocal, in part due to differences in the type and timing of hormone treatment. Here we cognitively tested aged female rhesus macaques on (1) the delayed response task of spatial working memory, (2) a visuospatial attention task that measured spatially and temporally cued reaction times, and (3) a simple reaction time task as a control for motor speed. After task acquisition, animals were ovariectomized (OVX). Their performance was compared with intact controls for 2 months, at which time no group differences were found. The OVX animals were then assigned to treatment with either a subcutaneous sham implant (OVX), 17-β estradiol (E) implant (OVX+E) or E implant plus cyclic oral progesterone (OVX+EP). All groups were then tested repeatedly over 12 months. The OVX+E animals performed significantly better on the delayed response task than all of the other groups for much of the 12 month testing period. The OVX+EP animals also showed improved performance in the delayed response task, but only at 30 s delays and with performance levels below that of OVX+E animals. The OVX+E animals also performed significantly better in the visuospatial attention task, particularly in the most challenging invalid cue condition; this difference also was maintained across the 12 month testing period. Simple reaction time was not affected by hormonal manipulation. These data demonstrate that chronic, continuous administration of E can exert multiple beneficial cognitive effects in aged, OVX rhesus macaque females.

Original languageEnglish (US)
Pages (from-to)10416-10424
Number of pages9
JournalJournal of Neuroscience
Volume36
Issue number40
DOIs
StatePublished - Oct 5 2016

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Cognitive Therapy
Macaca mulatta
Hormones
Reaction Time
Short-Term Memory
Cognition
Cues
Progesterone
Estradiol
Therapeutics

Keywords

  • Aging
  • Cognition
  • Hormones

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque. / Kohama, Steven; Renner, Lauren; Landauer, Noelle; Weiss, Alison R.; Urbanski, Henryk; Park, Byung; Voytko, Mary Lou; Neuringer, Martha.

In: Journal of Neuroscience, Vol. 36, No. 40, 05.10.2016, p. 10416-10424.

Research output: Contribution to journalArticle

Kohama, Steven ; Renner, Lauren ; Landauer, Noelle ; Weiss, Alison R. ; Urbanski, Henryk ; Park, Byung ; Voytko, Mary Lou ; Neuringer, Martha. / Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 40. pp. 10416-10424.
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