Effect of outflow tract banding on embryonic cardiac hemodynamics

Venkat Keshav Chivukula, Sevan Goenezen, Aiping Liu, Sandra Rugonyi

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori. In addition to the expected increase in ventricular blood pressure, and increase blood flow velocity and, thus, wall shear stress (WSS) at the band site, the characteristic peristaltic-like motion of the OFT was altered, further affecting flow and WSS. Myocardial contractility, however, was affected only close to the band site due to the physical restriction on wall motion imposed by the band. WSS were heterogeneously distributed in both normal and banded OFTs. Our results show how banding affects cardiac mechanics and can lead, in the future, to a better understanding of mechanisms by which altered blood flow conditions affect cardiac development leading to congenital heart disease.

Original languageEnglish (US)
Article number1
JournalJournal of Cardiovascular Development and Disease
Volume3
Issue number1
DOIs
StatePublished - Mar 2016

Keywords

  • Cardiac development
  • Cardiovascular development
  • Chicken embryonic heart
  • Computational fluid dynamics (CFD)
  • Congenital heart disease
  • Hemodynamics
  • Outflow tract

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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